Department：Neurosurgery
Medical School：Zhejiang University School of Medicine, China
Academic Rank：Chief Physician
Neurovascular diseases, including intracranial aneurysms, vascular malformations, carotid artery stenosis, moyamoya.
Member, Chinese Medical Association
Member, Chinese Medical Doctor Association
Dr Yu's research mainly focused on the potential mechanism and therapeutic strategy of secondary brain injury after intracerebral hemorrhage. Neuroinflammation is considered to be a critical component in the pathological process after intracerebral hemorrhage. Microglia are the foremost and earliest inflammatory cells participating in the pathological process of ICH. AdipoRon is the agonist of AdipoR1 (Adiponectin receptor 1), which enhances P-AMPK (phosphorylated AMP-activated protein kinase) activation. The activated AMPK facilitates microglia/macrophage polarization by driving the cell state from proinflammatory M1 state to anti-inflammatory M2 state. His recent work aims to investigate the role of AdipoRon in microglial polarization and neuroprotection after hyperglycemic intracerebral hemorrhage.
Zheng J, Sun Z, Liang F, Xu W, Lu J, Shi L, Shao A, Yu J, Zhang J*. AdipoRon Attenuates Neuroinflammation After Intracerebral Hemorrhage Through AdipoR1-AMPK Pathway. Neuroscience.2019 Aug 1;412:116-130.
Chen X, Lu X, Yan F, Xu W, Gao L, Zheng J, Yu J. Spontaneous thrombosis in main draining veins of unruptured cerebral arteriovenous malformations: A case report. Medicine (Baltimore). 2019 May;98(22):e15588.
Xu W, Lu X, Zheng J, Li T, Gao L, Lenahan C, Shao A, Zhang J*, Yu J*. Melatonin Protects Against Neuronal Apoptosis via Suppression of the ATF6/CHOP Pathway in a Rat Model of Intracerebral Hemorrhage. Front Neurosci. 2018 Sep 19;12:638.
Zheng J, Shi L, Liang F, Xu W, Li T, Gao L, Sun Z, Yu J*, Zhang J*. Sirt3 Ameliorates Oxidative Stress and Mitochondrial Dysfunction After Intracerebral Hemorrhage in Diabetic Rats. Front Neurosci. 2018 Jun 19;12:414.
Shi L, Liang F, Zheng J, Zhou K, Chen S, Yu J*, Zhang J*. Melatonin Regulates Apoptosis and Autophagy Via ROS-MST1 Pathway in Subarachnoid Hemorrhage. Front Mol Neurosci. 2018 Mar 26;11:93.
Shi L, Lei J, Xu H, Zheng J, Wang Y, Peng Y, Yu J*, Zhang J*. Hydrogen sulfide ameliorates subarachnoid hemorrhage-induced neuronal apoptosis via the ROS-MST1 pathway. Oncotarget. 2017 Aug 28;8(43):73547-73558.
Shi L#, Liang F, Li Y, Shao A, Zhou K, Yu J*, Zhang J*. Desmoteplase for Acute Ischemic Stroke within 3 to 9 Hours after Symptom Onset: Evidence from Randomized Controlled Trials. Sci Rep. 2016;6:33989.
Wang Z#, Shi L#, Ding W, Shao F, Yu J*, Zhang J. Efficacy of Progesterone for Acute Traumatic Brain Injury: a Meta-analysis of Randomized Controlled Trials. Mol Neurobiol. 2016;53(10):7070-7.
Chen S#, Hu J#, Xu L, Brandon D, Yu J*, Zhang J. Posterior Reversible Encephalopathy Syndrome After Transplantation: a Review. Mol Neurobiol. 2016;53(10):6897-909.
Chen S#, Pu JL, Yu J*, Zhang JM*. Multiple Aspergillus cerebellar abscesses in a middle-aged female: case report and literature review. Int J Med Sci. 2011;8(7):635-9.
AdipoR1 ameliorates secondary brain injury after intracerebral hemorrhage merging hyperglycemia. Funding Source: National Natural Science Foundation of China.
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The Second Affiliated Hospital
Zhejiang University School of Medicine
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+86-571-8731 5108
iao_sahzu@zju.edu.cn
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