Yu Hong, Ph.D.

Department:Cardiology, Lab of Cardiovascular Disease Diagnosis and Treatment

Medical School:Zhejiang University School of Medicine, China

Academic Rank:Professor


Clinical / Research Interests

Cardiovascular biology, molecular and cell biology, stem cell therapy, angiogenesis and tissue repair, aging and rejuvenation, analogs of growth hormone releasing hormone. 

Professional Highlights

Excellent Teaching Team, Zhejiang University, 2013

Major Achievement Award, Zhejiang University School of Medicine, 2016

Excellent Teaching Team, Zhejiang University, 2018

Zhejiang Province Health Science & Technology Innovation and Translation, Third Prize, 2019


Professional Appointments

Fellow, American Heart Association, 2012-present  

Education Experience

Research Summary

Hong Yu's research is focused on stem cell therapy for cardiovascular diseases, and the effects of aging on the activity of stem cells and their rejuvenation. He has been working on how to improve the activities of stem cells for better efficacy of cell therapy to cure cardiovascular diseases. His interested areas include promoting angiogenesis using stem cells, rejuvenation of aged stem cells, the roles of GDF11 in cardiac progenitor cells and cardiomyocytes, and effects of exosomes on stem cells and endothelial cells. He also studies the therapeutic effects of agonists of growth hormone releasing hormone on cardiovascular diseases and aging.

Publications

Zhang N, JY Zhu, QC Ma, Y Zhao, YC Wang, XY Hu, JH Chen, W Zhu, ZC Han, H Yu*. Exosomes derived from human umbilical cord MSCs rejuvenate aged MSCs and enhance their functions for myocardial repair. Stem Cell Res Ther, 2020: 11, 273. https://doi.org/10.1186/s13287-020-01782-9. 

Zhang C, Lin YN, Q Liu, He JH, PP Xiang, DL Wang, XY Hu, JH Chen,W Zhu, H Yu*.  Growth differentiation factor 11 promotes differentiation of MSCs into endothelial-like cells for angiogenesis.  J Cell Mol Med. 2020;00:1–15. doi.org/10.1111/jcmm.15502.

Zhao Y, JY Zhu, N Zhang, Q Liu, YC Wang, XY Hu, JH Chen,W Zhu, Hong Yu*. GDF11 enhances therapeutic efficacy of mesenchymal stem cells for myocardial infarction via YME1L-mediated OPA1 processing. Stem Cells Translational Medicine. (IF 6.429). 2020;1–15. doi: 10.1002/sctm.20-0005.

Lin YN, C Zhang, PP Xiang, J Shen, WJ Sun, H Yu*.  Exosomes derived from HeLa cells break down vascular integrity by triggering endoplasmic reticulum stress in endothelial cells. J Extracellular Vesicles. doi: 10.1080/20013078.2020.1722385.

Lv K, Li Q, Zhang L, Wang Y, Zhong Z, Zhao J, Lin X, Wang J, Zhu K, Xiao C, Ke C, Zhong S, Wu X, Chen J, Yu H, Zhu W, Li X, Wang B, Tang R, Wang J, Huang J, Hu X. Incorporation of small extracellular vesicles in sodium alginate hydrogel as a novel therapeutic strategy for myocardial infarction. Theranostics, 2019. October11, 9(24):7403-7416.

Hu L, Z Chen, Y Jin, B Jiang, X Wang, H Yu and X Yang. Incidence and predictors of aorta calcification in patients with systemic lupus erythematosus. Lupus (IF=2.969), 2019 Mar;28(3):275-282. doi: 10.1177/0961203319826689.

Su X, Y Jin, Y Shen, CW Ju, JW Cai, YT Liu, I Kim, Y Wang, H. Yu, NL Weintraub, M Jiang, YL Tang. Exosomes Derived Dystrophin from Allograft Myogenic Progenitors Improve Cardiac Function in Duchenne Muscular Dystrophic Mice.  J Cardiovas Transl Res. 2018. Aug 28. doi: 10.1007/s12265-018-9826-9.

Xiao CC, K Wang, YC Xu, HX Hu, N Zhang, YC Wang, ZW Zhong, J Zhao, QJ Li, D Zhu, CL Ke, SH Zhong, XP Wu, H Yu, W Zhu, JH Chen, JY Zhang, JA Wang, XY Hu. Transplanted mesenchymal stem cells reduce autophagic flux in infarcted hearts via the exosomal transfer of mir-125b. Circulation Research, August 16, 2018. 123:564-578.

Yang F, RR Wu, Z Jiang, J Chen, JL Nan, SA Su, N Zhang, C Wang, J Zhao, C Ni, YC Wang, WX Hu, ZR Zeng, KY Zhu, XB Liu, XY Hu, W Zhu, H Yu, and JY Huang, JA Wang. Leptin increases mitochondrial OPA1 via GSK3-mediated OMA1 ubiquitination to enhance therapeutic effects of mesenchymal stem cell transplantation. Cell Death Disease. 2018 May 1;9(5):556.

Shen J, N Zhang, YN Lin, PP Xiang, XB Liu, PF Shan, XY Hu, W Zhu, YL Tang, KA Webster, RZ Cai, A Schally, JA Wang, H Yu*. Regulation of Vascular Calcification by Growth Hormone-Releasing Hormone and its Agonists. Circulation Research, May 11, 2018. 122:1395-1408 ttps://doi.org/10.1161/CIRCRESAHA.117.312418.

Zhu K, Wu Q, Ni C, Zhang P, Zhong Z, Wu Y, Wang Y, Xu Y, Kong M, Cheng H, Tao Z, Yang Q, Liang H, Jiang Y, Li Q, Zhao J, Huang J, Zhang F, Chen Q, Li Y, Chen J, Zhu W, Yu H, Zhang J, Yang HT, Hu X, Wang J.  Lack of Remuscularization Following Transplantation of Human Embryonic Stem Cell-Derived Cardiovascular Progenitor Cells in Infarcted Nonhuman Primates. Circulation Research. 2018 Mar 30; 122(7):958-969.

Ruan Xf, Li YJ, Ju CW, Shen Y, Lei W, Chen C, Li Y, Yu H, Liu YT, Kim IM, Wang XL, Weintraub NL, Tang YL. Exosomes from Suxiao Jiuxin Pill-treated cardiac mesenchymal stem cells down-regulate H3k27 demethylase UTX expression in cardiomyocytes. Acta Pharmacologica Sinica. 2018,  Apr;39(4):579-586.

Ruan Xf, Ju CW, Shen Y, Liu YT, Kim IM, Yu H, Weintraub NL, Wang XL, Tang YL.   Suxiao Jiuxin pill promotes exosome secretion from mouse cardiac mesenchymal stem cells in vitro. Acta Pharmacologica Sinica. 2018, Apr;39(4):569-578.

JY Zhu, K Lu, N Zhang, Y Zhao, QC Ma, J Shen, YN Lin, PP Xiang, YL Tang, XY Hu, JH Chen , W Zhu, KA Webster, JA Wang, H Yu*.  Myocardial reparative functions of exosomes from mesenchymal stem cells are enhanced by hypoxia treatment of the cells via transferring microRNA-210 in an nSMase2-dependent way. Artif Cells Nanomed Biotechnol. 2018 Dec;46(8):1659-1670. doi: 10.1080/21691401.2017.1388249.

Hu DX, Nan JL, Sun Y, Zhu D, Xiao CC, Wang YP, Zhu LL, Wu Y, Zhao J, Wu RR, Chen JH, Yu H, Hu XY, Zhu W, Wang JA. Electron leak from NDUFA13 within mitochondrial complex I attenuates ischemia-reperfusion injury via dimerized STAT3. Proc Natl Acad Sci U S A, 2017, 2017, Nov 7;114(45):11908-11913.

Zhou Y, Chen PP, Liu QN, Wang YC, Zhang L, Wu RR, Chen JH, Yu H, Zhu W, Hu XY, and Wang JA. Hepatoma-Derived Growth Factor Secreted from Mesenchymal Stem Cells Reduces Myocardial Ischemia-Reperfusion Injury.  Stem Cells International, Vol. 2017, November Article ID 1096980, 12 pages, 2017. doi:10.1155/2017/1096980.

Chen Z, Li Y, Yu H, Shen Y, Ju C, Ma G, Liu Y, Kim IM, Weintraub NL, Tang Y.  Isolation of Extracellular Vesicles from Stem Cells.  Methods Mol Biol. 2017;1660:389-394.
Jin-Liang Nan; Wei Zhu; Rahman MS; Mingfei Liu; Sheng'an Su; Na Zhang; Dan Li; Xinyang Hu; Hong Yu; Mahesh P Gupta; Jian'an Wang. Molecular Regulation of Mitochondrial Dynamics in Cardiac Disease. BBA - Molecular Cell Research. 2017, Jul; 1864(7):1260-1273.

Hu DX, Z Zeng, W Zhu, N Zhang, H Yu, H Chen, K Wang, YC Wang, LM Wang, J Zhao, L Zhang, RR Wu, XY Hu, XB Liu, JA Wang.  SRT1720 Promotes Survival of Aged Human Mesenchymal Stem Cells via FAIM: a Pharmacological Strategy to Improve Stem Cell Based Therapy for Rat Myocardial Infarction. Cell Death and Disease. 2017 Apr 6;8(4):e2731. 

Yu H, K Lu, JY Zhu, JA Wang. Stem Cell Therapy for Ischemic Heart Disease. British Medical Bulletin. 2017, 121 (1): 135-154.  

Wang C, H Chen, W Zhu, MF Liu, YC Xu, LL Zhu, F Yang, L Zhang, XB Liu, Z Zhong, J Zhao, J Jiang, M Xiang, Yu H, X Hu, H Lu, and JA Wang*. Nicotine Accelerates Atherosclerosis in Apolipoprotein E-deficient Mice by Activating α7 Nicotinic Acetylcholine Receptor on Mast Cells. Arteriosclero Thromb Vasc Biol. 2017 Jan; 37(1):53-65.

Liu M, Chen H, Jiang J, Zhang Z, Wang C, Zhang N, Dong L, Hu X, Zhu W, Yu H, Wang J*. Stem cells and diabetic cardiomyopathy: from pathology to therapy. Heart Fail Rev. 2016 Nov;21(6):723-736.

Wang K, Jiang Z, Webster KA, Chen J, Hu H, Zhou Y, Zhao J, Wang L, Wang Y, Zhong Z, Ni C, Li Q, Xiang C, Zhang L, Wu R, Zhu W, Yu H, Hu X, Wang J*. Enhanced Cardioprotection by Human Endometrium Mesenchymal Stem Cells Driven by Exosomal MicroRNA-21. Stem Cells Transl Med. 2016 Aug 29. pii: sctm.2015-0386. 

Xia XY, Q Tao, Q Ma, H Chen, JA Wang, and Yu H*. Growth Hormone-Releasing Hormone and Its Analogues: Significance for MSCs-Mediated Angiogenesis, Stem Cells Int. 2016 Oct 20, Volume 2016 Article ID 8737589.

Ying-Mei Feng, Catherine Verfaillie, and Yu H. Vascular Diseases and Metabolic Disorders, Editorial. 2016 Oct 20, Volume 2016, Article ID 5810358.

Adi N, Adi J, Lassance-Soares RM, Kurlansky P, Yu H, Webster KA*. High protein/fish oil diet prevents hepatic steatosis in NONcNZO10 mice association with diet/genetics-regulated micro-RNAs.  J Diabet Metabol. 2016 Jun 16, 7:676; DOI: 10.4172/2155-6156.1000676.

Boden J, Lassance-Soares RM, Wang H, Wei Y, Spiga MG, Adi J, Layman H, Yu H, Vazquez-Padron RI, Andreopoulos F, Webster KA*. Vascular Regeneration in Ischemic Hindlimb by Adeno-Associated Virus Expressing Conditionally Silenced Vascular Endothelial Growth Factor. J Am Heart Assoc. 2016 May 26;5(6). pii: e001815. doi: 10.1161/JAHA.115.001815.

Hu X, Chen P, Wu Y, Wang K, Xu Y, Chen H, Zhang L, Wu R, Webster KA, Yu H, Zhu W, Wang J*.  MiR-211/STAT5A Signaling Modulates Migration of Mesenchymal Stem Cells to Improve its Therapeutic Efficacy. Stem Cells. 2016 May 3. 34(7):1846-58.  doi: 10.1002/stem.2391.

Ma Q, X Xia, Q Tao, K Lu, J Shen, Q Xu, X Hu, Y Tang, NL Block, KA Webster, AV Schally, Wang J, Yu H*. Profound actions of an agonist of growth hormone releasing hormone on angiogenic therapy by mesenchymal stem cells. Arteriosclero Thromb Vasc Biol. 2016 Apr;36:663-672.

Hu X, Y Xu, ZW Zhong, Y Wu, J Zhao, Y Wang, HF Cheng, MJ Kong, FJ Zhang, Q Chen, JZ Sun, Q Li, J Jin, QJ Li, LH Chen, C Wang, HW Zhan, Y Fan, Q Yang, L Yu, RR Wu, J Liang, JY Zhu, Y Wang, YP Jin, YF Lin, F Yang, LL Jian, W Zhu, JH Chen, H Yu, JY Zhang, J Wang*. A Large-scale Investigation of Hypoxia-preconditioned Allogeneic Mesenchymal Stem Cells for Myocardial Repair in Non-human Primates: Paracrine Activity Without Remuscularization.  Circ Res. 2016, Mar 18, 118(6):970-83.

Yang ZX, Wang YZ, Jia BB, Mao GX, Lv YD, Wang GF, Yu H*. Down-regulation of miR-146a,COX-2 and AGEs in simvastatin treated elder patients with hyperlipidemia  Geriatrics & Gerontology International  2016; 16:322-328.. doi: 10.1111/ggi.12472.

Yu H, K Lu, JA Wang. Treatment of heart failure after myocardial infarction with bone marrow-derived mesenchymal stem cells (Review). Cardiol Plus. 2015 Sept; 1(1)17-23.

Yu H, JY Zhu, JA Wang. Update of Stem Cell Therapy for Ischemic Heart Failure. Chin J Intervent Cardiol. May 2015, 23 (5):286-290. Review 

Thompson JW, Wei J, Appau K, Wang H, Yu H, Spiga MG, Graham RM, Webster KA*.  Bnip3 Binds and Activates p300: Possible Role in Cardiac Transcription and Myocyte Morphology.  PLoS One. 2015 Aug 28;10(8):e0136847.

Hu X, L Zhang, J Jin, W Zhu, Y Xu, Y Wu, Y Wang, H Chen, KA.Webster, H Chen, H Yu, J Wang*. Heparanase released from mesenchymal stem cells activates intergrin beta1/HIF-2alpha/Flk-1 signaling and promotes endothelial cell migration and angiogenesis. Stem Cells. 2015, Jun;33(6):1850-62. 

Liu X, Chen H, Zhu W, Chen H, Hu X, Jiang Z, Xu Y, Zhou Y, Wang K, Wang L, Chen P, Hu H, Wang C, Zhang N, Ma Q, Huang M, Hu D, Zhang L, Wu R, Wang Y, Xu Q, Yu H, Wang J*. Transplantation of SIRT1-engineered aged mesenchymal stem cells improves cardiac function in a rat myocardial infarction model. J Heart Lung Transplant. 2014 Oct; 33(10):1083-92. 

X Hu, R Wu, Z Jiang, L Wang, P Chen, L Zhang, L Yang, Y Wu, H Chen, H Chen, Y Xu, Y Zhou, X Huang, KA Webster, H Yu*, JA Wang*. Leptin signaling is required for augmented therapeutic properties of mesenchymal stem cells conferred by hypoxia preconditioning. Stem Cells, July 3, 2014; 32:2702–2713.

Chen P, Wu R, Zhu W, Jiang Z, Xu Y, Chen H, Zhang Z, Chen H, Zhang L, Yu H, Wang J, X Hu *. Hypoxia preconditioned mesenchymal stem cells prevent cardiac fibroblast activation and collagen production via leptin. PLoS One. 2014 Aug 12;9(8):e103587. doi: 10.1371/journal.pone.0103587.

Chen H, Liu X, Zhu W, Chen H, Hu X, Jiang Z, Xu Y, Wang L, Zhou Y, Chen P, Zhang N, Hu D, Zhang L, Wang Y, Xu Q, Wu R, Yu H, Wang J*. SIRT1 ameliorates age-related senescence of mesenchymal stem cells via modulating telomere shelterin.  Front Aging Neurosci. 2014 Jun 3;6:103. doi: 10.3389/fnagi.2014.00103.

Zhang N, Xie X, Chen H, Chen H, Yu H, Wang JA. Stem cell-based therapies for atherosclerosis: perspectives and ongoing controversies。Stem Cells Dev. 2014 Aug 1;23(15):1731-40. doi: 10.1089/scd.2014.0078. Epub 2014 May 22.

X Hu, R Wu, LA Shehadeh, Q Zhou, C Jiang, X Huang, L Zhang, F Gao, X Liu, H Yu, KA Webster, and J Wang. Severe Hypoxia Exerts Parallel and Cell-specific Regulation of Gene Expression and Alternative Splicing in Human Mesenchymal Stem Cells Mesenchymal Stem Cells. BMC Genomics 2014, 15:303.

MS Zhou, A Wang, H Yu. Link between Insulin Resistance and Hypertension: What is the Evidence from Evolutionary Biology? Diabetology & Metabolic Syndrome.  2014 Jan 31,6:12. 1-8.  doi:10.1186/1758-5996-6-12.

Xu Y, Hu X, Wang L, Jiang Z, Liu X, Yu H, Zhang Z, Chen H, Chen H, Steinhoff G, Li J, Jian'an Wang.  Preconditioning via Angiotensin Type 2 Receptor Activation Improves Therapeutic Efficacy of Bone Marrow Mononuclear Cells for Cardiac Repair. PLoS One. 2013 Dec 10;8(12):e82997. doi: 10.1371/journal.pone.0082997.

Z Jiang, X Hu, H Yu, Y Xu, L Wang, H Chen, H Chen, R Wu, Z Zhang, C Xiang, KA Webster and J Wang. Human endometrial stem cells confer enhanced myocardial salvage and regeneration by paracrine mechanisms. J Cell Mol Med. 2013 Oct;17(10):1247-60. doi: 10.1111/jcmm.12100.

Xu YC#, Hu XY#, Wang LH, Jiang Z, Liu X, Yu H, Zhang Z, Chen H, Chen H, Steinhoff G, Li J*, Wang JA*. Transplantation of preconditioned bone marrow mononuclear cells by AT2R stimulation improves infarcted heart function via enhanced cardiac mobilization of implanted cells. Intl J Cardiology. 2013 Oct 9;168(4):4551-4.

Z Zhang, J Wang, Y Xu, Z Jiang, R Wu, L Wang, P Chen, X Hu, H Yu. Menstrual blood derived mesenchymal cells ameliorate cardiac fibrosis via inhibition of endothelial to mesenchymal transition in myocardial infarction.  Intl J Cardiol 2013 Sep 30;168(2):1711-4. doi: 10.1016/j.ijcard.2013.03.126. 

X Lin, Y Wang, Y Zhang, B Huang, JJ Lin, SJ Hallock, H Yu, H Shao, J Yan, B Huang, XC Zhang, W Cao, X Xu, X Lin. Purification and characterization of mutant miniPlasmin for thrombolytic therapy  Thrombosis Journal  2013, 11:2.

Yu H Shao H, Yan J, Tsoukias NM, Zhou MS  Bone Marrow Transplantation Improves Endothelial Function in Hypertensive Dahl Salt-Sensitive Rats.  J Am Soc Hypertension. 2012 Sep;6(5):331-7. doi: 10.1016/j.jash.2012.08.003.

Xu Q, Wang JA, He J, Zhou MS, Adi J, Webster K, Yu H.* Impaired CXCR4 Expression and Cell Engraftment of Bone Marrow-derived Cells from Aged Atherogenic Mice. Atherosclerosis. 219:92-99, 2011.

Cesar L, SV Suarez, J Adi, N Adi, R Vasquez-Padron, H Yu, Q Ma, PJ Goldschmidt-Clermont,  AAP Kurlansky, and  Webster*, KA. An essential role for diet in exercise-mediated protection against dyslipidemia, inflammation and atherosclerosis in ApoE-/- Mice. PLoS ONE, 6(2): e17263. doi:10.1371/journal.pone.0017263, 2011. 

Shao H, Xu Q, Wu Q, Ma Q, Slgueiro L, Wang JA, Eton D, Webster K, Yu H.* Defective CXCR4 Expression in Aged Bone Marrow Cells Impairs Vascular Regeneration. J Cell Mol Med. 15(10):2046-2056, 2011.

Yang Z, Huang CY, Candiotti KA, Zeng X, Yuan T, Li J, Yu H, Abdi S *. Sox-9 facilitates differentiation of adipose tissue-derived stem cells into a chondrocyte-like phenotype in vitro.  J Orthopedic Res; 29(8):1291-7. 2011.

Wilson A, Shehadeh, L, Yu H. and Webster, KA*. Age-Related Changes in the Molecular Genetic Profiles of Murine Bone Marrow Mesenchymal Stem Cells. BMC Genomics,  11:229; 2010. 

Wu Q, Ma Q, Shehadeh LA, Wilson A, Xia L, Yu H, Webster KA*.  Expression of the Argonaute Protein Piwl2 and piRNAs in Adult Mouse Mesenchymal Stem Cells.  Biochem Biophys Res Commun. 396(4):915-20; 2010.

Eton D, Yu H. Enhanced Cell Therapy Strategy to Treat Chronic Limb Threatening Ischemia. J Vasc Surg. 52(1):199-204; 2010 doi:10.1016/j.jvs.2009.12.048.

Yu, H#, Azatian A, Dai W, Schneiders FI, Lord R*. Effectiveness of HSV-tk suicide gene therapy driven by the Grp78 stress-inducible promoter in esophagogastric junction and gastric adenocarcinomas.  J Gastrointest Surg. 13(6):1044-1051. 2009. 

Tan, Y, Y. Li, J Xiao, H Shao, C Ding, GE Arteel, KA Webster, J Yan, H Yu, L Cai and X Li. A novel CXCR4 antagonist derived from human SDF-1 enhances angiogenesis in ischemic mice.  Cardiovascular Res. 82(3):513-521. 2009.

Wu Q., Shao H, D. Eton, J Li. B Yang, M. G. Uberti, KA Webster, H. Yu*  Extracellular calcium increases CXCR4 Expression on Bone Marrow-derived Cells and Enhances Pro-Angiogenesis Therapy.  J Cell Mol Med. 13(9B):3764-3773. 2009.

Yu H.*, Feng Y.  The Potential of Statin and Stromal Cell-derived Factor-1 to Promote Angiogenesis. Cell Adhesion and Migration. 2 (4):254-257, 2008.

Shao H, Tan, Y, D. Eton, Z. Yang, M. G. Uberti, S Li, A. Schulick, H. Yu*  Statin and Stromal Cell Derived Factor-1 Additively Promote Angiogenesis by Enhancement of Progenitor Cells Incorporation into New Vessels.  Stem Cells. 26(5):1376-1384, 2008 May.

Yang Z, H Shao, Y Tan, D Eton, H. Yu*.  Blood-Derived Smooth Muscle Cells as a Target for Gene Delivery.  J. Vas Surg.  47(2): 432-40, 2008.

Tan Y, Shao H, Eton D, Yang Z, Zhang HK, Alonzo-Diaz L, Schulick A, Livingstone AS, Yu H*. Stromal Cell-Derived Factor-1 Enhances Pro-Angiogenic Effect of Granulocyte Colony Stimulating Factor.  Cardiovascular Res. 73(4): 823-832, 2007.

Yang, Z. Eton D, Zheng F, Livingstone AS, Yu H*.  Effect of tissue plasminogen activator on vascular smooth muscle cells. J. Vas Surg; 42(3): 532-8, 2005.

Yu H*, Dai W, Yang Z, Romaguera RL, Kirkman P, Rowe VL. Neointimal Hyperplasia on a Cell-Seeded PTFE Graft is Promoted by Transfer of Tissue Plasminogen Activator Gene and Inhibited by Transfer of Nitric Oxide Synthase Gene.  J. Vas Surg; 41(1): 122-129, 2005.

Yu H#, Eton D*, Wang Y, Raines J, Striker G, Livingstone A. Endograft technology: a delivery vehicle for intravascular gene therapy. J Vasc Surg; 39(5): 1066-73, 2004. 

Zheng F*, Cheng QL, Plati AR, Ye SQ, Berho M, Banerjee A, Potier M, Jaimes EA, Yu H, Guan Y, Hao CM, Striker LJ, Striker GE.  The Glomerulosclerosis of Aging in Females: Contribution of the Proinflammatory Mesangial Cell Phenotype to Macrophage Infiltration.  Am J Pathol; 165: 1789-98, 2004.

Dong D, Dubeau L, Bading J, Nguyen K, Luna M, Yu H, Gazit-Bornstein G, Gordon E M., Gomer C, Hall F L., Gambhir S, And Lee A S *.  Spontaneous and Controllable Activation of Suicide Gene Expression Driven by the Stress-inducible Grp78 Promoter Resulting in Eradication of Sizable Human Tumors. Human Gene Therapy.  15: 553-561, June 2004.

Yu H., W. Dai, Z. Yang, P. Kirkman, FA Weaver, D. Eton, VL. Rowe. Smooth muscle cells improve endothelial cell retention on polytetrafluoroethylene grafts in vivo. J. Vas Surg  38 (3): 557-563, 2003.

Kwon, Y, G. Hung, WF Anderson, C. Peng, H. Yu*.  Determination of infectious retroviral concentration from colony-forming assay with quantitative analysis.  J. Virol  May, 77(10):5712-20, 2003.

Wu, GD, JA Nolta, YS Jin, ML Barr, H. Yu, VA. Starnes, and DV Cramer*.  Migration of Mesenchymal Stem Cells to Heart Allografts during Chronic Rejection. Transplantation.  75 (5): 679-684, 2003.

Chen L, Yu H, Dai N, Tao SF, Gong WH. Dual cell seeding to improve cell retention on polytetrafluoroethylene grafts. Zhonghua Wai Ke Za Zhi. 41(2):143-5, 2003.

Yu, H., SR Kumar, L Tang, TT Terramani, VL Rowe, Y. Wang, F.A. Weaver, D. Eton. Injury induced neointima formation and its inhibition by transfer of nitride oxide synthase gene in an in-vitro human saphenous vein culture model. Atherosclerosis. 161: 113-122, 2002.

Yu, H., Y. Wang, D. Eton, V.R. Rowe, D.V. Cramer, V.A. Starnes, F.A. Weaver.  Dual cell seeding and the use of zymogen tissue plasminogen activator to improve cell retention on polytetrafluoroethylene grafts.  J. Vas Surg 34 (8): 337-343, 2001.

Kwon, Y. J., H. Yu, C.A. Peng*.  Enhanced Retroviral Transduction of 293 Cells Cultured on Liquid-Liquid Interface.  Biotechnology and Bioengineering, 72 (3): 331-338, 2001.

Terramani, T.T., P A Bui, D. Eton, Y. Wang, F. A. Weaver, H. Yu*. Human Macrovascular Endothelial Cells: Optimization of Culture Conditions.  In Vitro Cell. Dev. Biol.--Animal, 35 (2): 125-132, 2000.

Yu, H., D. Eton, Y. Wang, T Terramani, C. Benedict, and W. F. Anderson.  High efficient in vitro gene transfer into vascular tissue using a pseudotyped retroviral vector without pseudotransduction. Gene Therapy, 6 (11): 1876-1883, 1999.

Yu H, Y. Wang, D. Eton, M. Stins, L. Wang and B.V. Zlokovic*. Retroviral Vector-Mediated Transfer and Expression of Human Tissue Plasminogen Activator Gene in Bovine Brain Endothelial Cells. Neurosurgery, 45 (4): 962-970, 1999.

*Eton D, TT Terramani, Y Wang, A Takahashi, L Tang, FA Weaver, H Yu. Genetic engineering of stent-grafts with a highefficiency pseudotyped retroviral vector. J Vas Surg, 29 (5): 863 –873, 1999.

Terramani, T.T., Rowe, V., Hood, D., Eton, D., Nuno, I., H. Yu, Yellin, A., Starnes, V., & Weaver, F.A*. Combined carotid endarterectomy and coronary artery bypass grafting in asymptomatic carotid artery stenosis. American Surgeon, 64:993-997, 1998.

Yu, H., C. Empig, J. Xia, and W. F. Anderson*. Quantitation of MoMuLV Envelope Protein on the Cell Surface. Virology.  243:415-422, 1998.

Ragheb, J. A., H. Yu, T. Hofmenn, W. F. Anderson*.   The Amphotropic and  Ecotropic Murine Leukemia Virus Envelope TM Subunits Are Equivalent Mediators of Direct Membrane Fusion: Implications for the Role of the Ecotropic Envelope and Receptor in Syncytium Formation and Viral Entry.  J. Virol.  69 (11), 7205-7215, 1995.

Yu, H., N. Soong, W. F. Anderson*.  Binding kinetics of ecotropic (Moloney) murine leukemia retrovirus with NIH 3T3 cells.  J. Virol.  69 (10), 6557-6562, 1995.

Cai, H., H. Yu, K. McEntee, M. F. Goodman*.  Purification of E. coli DNA polymerase II. Methods in Enzymology.  262, 13-21, 1995.

Cai, H., H. Yu, K. McEntee, T. A. Kunkel, M. F. Goodman*.  Purification and  Properties of Wild-type and Exonuclease-deficient DNA Polymerase II from Escherichia coli. J. Biol. Chem.  270 (23), 15327-15335, 1995.

Anderson, W. F., D. B. Prince, H. Yu, K. McEntee, M. F, Goodman*.  Crystallization of DNA polymerase II from Escherichia coli.  J. Mol. Biol.  238 (1), 120-122, 1994.

Yu, H., R. Eritja, L. B. Bloom, M. F. Goodman*.  Ionization of bromouracil and fluorouracil stimulates base mispairing frequencies with guanine.  J. Biol. Chem.  268 (21), 15935-43, 1993.  

Yu, H., M. F. Goodman*.  Comparison of HIV and AMV reverse transcriptase fidelity on RNA and DNA templates.  J. Biol. Chem. 267 (15), 10888 – 10896, 1992.

Yu, H., N. Yang, W. Ying, Z. Du.  Transformation of Corynebacterium protoplasts with plasmid pXA10145 DNA. Chinese J. Biotech. 5(1), 51-56, 1989.  

Yu, H., X. Fang, N. Yang.  A modified method for purification of plasmid DNA in Corynebacteriium pekinese.  Microbiology  15(2), 88-89, 1988.

Yu, H., X. Fang, Z. Du. Application of genetic engineering on producing high amino acid-yield bacterial strains (review). Chinese J. Biotech. 3(3), 161-168, 1987.  

*Wu, Z., H. Yu, X. Chen. Radiation of Micromonspora echinospora with copper vapor laser light. Chinese J. Lasers  12(11), 654-657, 1985.  

Du, Z., Z. Wu, H. Yu, X. Chen*. The mutational effect of UV and LiCl on the protoplast of Corynebacterium Pekinese. Chinese J. Biotech.  1(4), 59-62, 1985. 


Current Program

Differentiation regulation of human pluripotoent stem cells into functional heart cells and their safety and efficiency after implantation. Funding Source: Minister of Science and Technology of China.

Effect of hypoxia treatment on the content of exosome secreted from mesenchymal stem cells: the role of leptin. Funding Source: National Natural Science Foundation of China.

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