Ye Zhaoming, M.D., Ph.D.

Position:Chair of Orthopaedics


Medical School:Zhejiang University School of Medicine, China

Academic Rank:Professor, Chief Physician


Clinical / Research Interests

Diagnosis and surgical treatment of musculoskeletal tumors, especially limb salvage and biological reconstruction after pelvic tumor resection.

Professional Highlights

Qiushi Distinguished Physician of Zhejiang University 

Professional Appointments

Chairman, Orthopedic Committee of Zhejiang Medical Association, 2019-present

Standing Member, Orthopedic Committee of the Chinese Medical Doctor Association, 2019-present

Vice Chairman, The First Committee of Orthopedic Oncology Society, SICOT China Chapter

Deputy Chief Editor, World Journal of Emergency Medicine, 2019-present

Editorial Board Member, Orthopaedic Surgery, 2017-present

Chairman, Bone and Soft Tissue Committee of Zhejiang Anticancer Association, 2017-present

Education Experience

Research Summary

Immunotherapy of musculoskeletal tumors;

Multi-omics studies of musculoskeletal tumors (including imaging, pathology, proteomics;

Engineering and product development of bone induction and intelligent antibacterial active bone implantation devices.


Chen T, Guo J, Cai Z, Li B, Sun L, Shen Y, Wang S, Wang Z, Wang Z, Wang Y, Zhou H, Cai Z, Ye Z. Th9 Cell Differentiation and Its Dual Effects in Tumor Development. Front Immunol. 2020 May 20;11:1026. 

Teng W, Lin P, Li Y, Yan X, Li H, Li B, Wang Z, Wu Y, Wang S, Zhou X, Wang Z, Ye Z. Bone combined cement grafting in giant cell tumor around the knee reduces mechanical failure. Int Orthop. 2019 Feb;43(2):475-482. 

Wang Z, Wang Z, Li B, Wang S, Chen T, Ye Z. Innate Immune Cells: A Potential and Promising Cell Population for Treating Osteosarcoma. Front Immunol. 2019 May 16;10:1114. 

Wu Y, Xu L, Yang P, Lin N, Huang X, Pan W, Li H, Lin P, Li B, Bunpetch V, Luo C, Jiang Y, Yang D, Huang M, Niu T, Ye Z. Survival Prediction in High-grade Osteosarcoma Using Radiomics of Diagnostic Computed Tomography. EBioMedicine. 2018 Aug;34:27-34. 

Li B, Wang Z, Wu H, Xue M, Lin P, Wang S, Lin N, Huang X, Pan W, Liu M, Yan X, Qu H, Sun L, Li H, Wu Y, Teng W, Wang Z, Zhou X, Chen H, Poznansky MC, Ye Z. Epigenetic Regulation of CXCL12 Plays a Critical Role in Mediating Tumor Progression and the Immune Response In Osteosarcoma. Cancer Res. 2018 Jul 15;78(14):3938-3953. 

Wang Z, Wang Z, Li S, Li B, Sun L, Li H, Lin P, Wang S, Teng W, Zhou X, Ye Z. Decitabine Enhances Vγ9Vδ2 T Cell-Mediated Cytotoxic Effects on Osteosarcoma Cells via the NKG2DL-NKG2D Axis. Front Immunol. 2018 Jun 1;9:1239. 

Lin N, Li H, Li W, Huang X, Liu M, Yan X, Pan W, Yang D, Ye Z. Upshifting the Ipsilateral Proximal Femur May Provide Satisfactory Reconstruction of Periacetabular Pelvic Bone Defects After Tumor Resection. Clin Orthop Relat Res. 2018 Sep;476(9):1762-1770. 

Wang S, Li H, Ye C, Lin P, Li B, Zhang W, Sun L, Wang Z, Xue D, Teng W, Zhou X, Lin N, Ye Z. Valproic Acid Combined with Zoledronate Enhance γδ T Cell-Mediated Cytotoxicity against Osteosarcoma Cells via the Accumulation of Mevalonate Pathway Intermediates. Front Immunol. 2018 Feb 27;9:377.

Wang Z, Li B, Ren Y, Ye Z. T-Cell-Based Immunotherapy for Osteosarcoma: Challenges and Opportunities. Front Immunol. 2016 Sep 14;7:353.

Li HY, Zhang J, Sun LL, Li BH, Gao HL, Xie T, Zhang N, Ye ZM. Celastrol induces apoptosis and autophagy via the ROS/JNK signaling pathway in human osteosarcoma cells: an in vitro and in vivo study. Cell Death Dis. 2015 Jan 22;6(1):e1604.

Current Program

Musculoskeletal system repair materials and implanted instruments, and engineering techniques for surface modification. Funding Source: National Key R&D Program of China. 

The role of γδ T cells as novel antigen-presenting cells in inducing anti-osteosarcoma immune response and the mechanism of antigen presentation. Funding Source: National Natural Science Foundation of China.

Research and application of 3D printing integrated manufacturing technology for personalized medical aids. Funding Source: Key R&D Project of Zhejiang Provincial Department of Science and Technology.

Anti-osteosarcoma effect and mechanism of a novel tumor vaccine with porous nano-silicon loaded antigen presented by γδ T cells. Funding Source: Zhejiang Provincial Medicine and Health Science and Technology Project.

Demethylation therapy induces CTA-specific γδ T cells to recognize the osteosarcoma and its mechanisms. Funding Source: Natural Science Foundation of Zhejiang.

Based on the MOOC platform and the application of the flipped classroom to strengthen the practical ability in orthopedics clinical practice teaching. Funding Source: The First Batch of Teaching Reform Research Projects of the "13th Five-Year Plan" of Zhejiang Higher Education.

Basic research of adoptive transferring αβ TCR gene transfection γδ T cells for osteosarcoma. Funding Source: National Natural Science Foundation of China.

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