Yao Ke, M.D.

Position: Chair of Ophthalmology

Department: Ophthalmology

Medical School: Shanghai Second Medical University, China

Academic Rank: Professor, Chief Physician


Clinical / Research Interests

Anterior segment eye diseases including cataract and glaucoma.

Professional Highlights

State Scientific and Technological Progress Award, Second Prize

Zhejiang Scientific and Technological Progress Award, First Prize

Zhejiang Province Extraordinary Contributor for Science and Technology

Alfred Vogt-Prize, Switzerland

ICO Mark Tso Golden Apple Award

APACRS Golden Award


Italian Ophthalmic Society Antonio SCARPA Medal

International Lecture Medal

US-Sino Ophthalmology Golden Key Award

US-Sino Ophthalmology Golden Apple Award

Outstanding Achievement Award of COS

Chinese Physician Award

Professional Appointments

Chair, Chinese Ophthalmological Society

Chair, Chinese Cataract Society, 2007-present

Committee Member, International Council of Ophthalmology

Member, Academia Ophthalmologica Internationalis

Regional Secretary, Asia-Pacific Academy of Ophthalmology

President, Asia-Pacific Association of Cataract & Refractive Surgeons

Council Member, Academy of Asia-Pacific Professors of Ophthalmology

Member, International Intra-Ocular Implant Club

Chair, Zhejiang Association for Science and Technology

Chair, Zhejiang Medical Association

Editor-in-Chief, Ophthalmology (Chi)

Editor-in-Chief, EyeWorld in Asia-Pacific Version (Chi)

Editor-in-Chief, Chinese Journal of Ophthalmology (Chi)

Deputy Editor-in-Chief, International Journal of Ophthalmology

Deputy Editor-in-Chief, Chinese Journal of Experimental Ophthalmology (Chi)

Editor, Graefe's Archive for Clinical and Experimental Ophthalmology

Editor, Asia-Pacific Journal of Ophthalmology

Editor, Translational Vision Science & Technology

Editor, Ophthalmic Research

Education Experience

Research Summary

Screening and function investigation of congenital cataract linked mutation from cataract patients;

Molecular mechanism investigation of human lens development and congenital cataract progress using iPSCs derived regenerative lens through our newly developed 'fried egg' lentoid body differentiation method;

Investigation of the pathogenic mechanisms of age-related cataract;

Invention of IOLs loaded with sustained-release drugs using 3D printing, layer-by-layer method, etc.


Danni Lyu, Siham Almansoob, Hui Chen, Yang Ye, Fan Song, Lifang Zhang, Zhenwei Qin, Qiaomei Tang, Houfa Yin, Wen Xu, Zhijian Chen, Ke Yao 3*, Qiuli Fu 4*. Transcriptomic Profiling of Human Corneal Epithelial Cells Exposed to Airborne Fine Particulate Matter (PM 2.5). Ocul Surf. 2020 Jun 18;S1542-0124(20)30100-2.

Siyu Liu, Chenyang Hu, Yueqiu Luo, Ke Yao*. Genome-wide DNA Methylation Profiles May Reveal New Possible Epigenetic Pathogenesis of Sporadic Congenital Cataract. Epigenomics. 2020 Jun 9. 

Yueyang Zhong, Kai Wang, Yanan Zhu, Danni Lyu, Ke Yao*. COVID-19 and the Eye. J Infect. 2020 May 28;S0163-4453(20)30331-5.

Yue-Ye Wang, Ke-Yao Zhou, Yang Ye, Fan Song, Jin Yu, Jin-Cao Chen, Ke Yao*. Moyamoya Disease Associated With Morning Glory Disc Anomaly and Other Ophthalmic Findings: A Mini-Review. Front Neurol. 2020 May 15;11:338. 

Yue Huang, Qiang Gao, Xu Li1, Yifan Gao, Haijie Han, Qiao Jin*, Ke Yao, and Jian Ji. Ofloxacin loaded MoS2 nanoflakes for synergistic mild-temperature photothermal/antibiotic therapy with reduced drug resistance of bacteria. Nano Res. (2020).

Haijie Han, Qichuan Yin, Xiajing Tang, Xiaoning Yu, Qiang Gao, Yelei Tang, Andrzej Grzybowski, Ke Yao, Jian Ji, Xingchao Shentu*. Development of Mucoadhesive Cationic Polypeptide Micelles for Sustained Cabozantinib Release and Inhibition of Corneal Neovascularization. J. Mater. Chem. B, 2020,8, 5143-5154.

Dengfeng Hu, Lingyun Zou, Weijiang Yu, Fan Jia, Haijie Han, Ke Yao, Qiao Jin, Jian Ji*. Relief of Biofilm Hypoxia Using an Oxygen Nanocarrier: A New Paradigm for Enhanced Antibiotic Therapy. Adv. Sci. 2020.

Yang X, Xu J, Fu C, Jia Z, Yao K*, Chen X*. The cataract-related S39C variant increases γS-crystallin sensitivity to environmental stress by destroying the intermolecular disulfide cross-links. Biochem Biophys Res Commun. 2020 Mar 28. 526 (2020) 459-465.

Song X, Liu X, Wang W, Zhu Y, Qin Z, Lyu D, Shentu X, Xv W, Chen P, Yao KE*. Visual Outcome and Optical Quality after Implantation of Zonal Refractive Multifocal and Extended Range of Vision Intraocular Lenses: A Prospective Comparison. J Cataract Refract Surg. 2020 Jan 30. 

Qiao Y, He J, Chen W, Yu Y, Li W, Du Z1, Xie T, Ye Y, Hua SY, Zhong D, Yao K, Zhou M*. Light-Activatable Synergistic Therapy of Drug-Resistant Bacteria-Infected Cutaneous Chronic Wounds and Nonhealing Keratitis by Cupriferous Hollow Nanoshells. ACS Nano. 2020 Mar 24;14(3):3299-3315. 

Tang X#, Lou L#, Xu Y, Jin K, Cao J, Shao J, Gao Z, Yao K*. Socioeconomic inequality in the global burden of refraction disorders: results from the Global Burden of Diseases Study 2017. Acta Ophthalmol. 2020 Mar 1. 

Li J, Chen X, Yan Y, Yao K*. Molecular genetics of congenital cataracts. Exp Eye Res. 2020 Feb;191:107872. 

Lin Y, Xu CL, Breazzano MP, Tanaka AJ, Ryu J, Levi SR, Yao K, Sparrow JR, Tsang SH*. Progressive RPE atrophy and photoreceptor death in KIZ-associated autosomal recessive retinitis pigmentosa. Ophthalmic Genet. 2020 Feb;41(1):26-30. 

Chen H, Chen X, Wang H, Fang Z, Yao K*. Intraocular Lens power calculation after laser refractive surgery: A Meta-Analysis. Sci Rep. 2020 Feb 14;10(1):2645. doi: 10.1038/s41598-020-59487-1.

Lyu D, Shen Z, Zhang L, Qin Z, Ni S, Wang W, Zhu Y, Yao K*. Comparison of Perioperative Parameters in Femtosecond Laser-assisted Cataract Surgery using Three Nuclear Fragmentation Patterns. Am J Ophthalmol. 2019 Dec 27. pii: S0002-9394(19)30618-X. 

Lin Y, Weng K, Liang J, Zhou Y, Hao Q, Hao Y, Yao K*, Zou J*. The extracellular and intracellular regions of Crb2a play distinct roles in guiding the formation of the apical zonula adherens. Biomed Pharmacother. 2020 May;125:109942. 

Ye P, Xu J, Luo Y, Su Z, Yao K*. Familial autosomal recessive bestrophinopathy: identification of a novel variant in BEST1 gene and the specific metabolomic profile. BMC Med Genet. 2020 Jan 22;21(1):16. 

Lai KR, Zhang XB, Yu YH, Yao K*. Comparative clinical outcomes of Tecnis toric IOL implantation in femtosecond laser-assisted cataract surgery and conventional phacoemulsification surgery. Int J Ophthalmol. 2020 Jan 18;13(1):49-53. 

He J, Qiao Y, Zhang H, Zhao J, Li W, Xie T, Zhong D, Wei Q, Hua S, Yu Y, Yao K, Santos HA*, Zhou M*. Gold-silver nanoshells promote wound healing from drug-resistant bacteria infection and enable monitoring via surface-enhanced Raman scattering imaging. Biomaterials. 2020 Mar;234:119763. 

Liu X, Song X, Wang W, Zhu Y, Lyu D, Shentu X, Chen P, Yu Y, Yao K*. Comparison of the Clinical Outcomes between Echelette Extended Range of Vision and Diffractive Bifocal Intraocular Lenses. J Ophthalmol. 2019 Sep 23;2019:5815040. 

Lu B, Yin H, Tang Q, Wang W, Luo C, Chen X, Zhang X, Lai K, Xu J, Chen X, Yao K*. Multiple cytokine analyses of aqueous humor from the patients with retinitis pigmentosa. Cytokine. 2019 Dec 3;127:154943. 

Zhang K, Zhao WJ, Yao K*, Yan YB. Dissimilarity in the Contributions of the N-Terminal Domain Hydrophobic Core to the Structural Stability of Lens β/γ-Crystallins. Biochemistry. 2019 May 21;58(20):2499-2508. 

Ye PP, Xu J, Su ZT, Fang XY1,2, Yao K1,2*. The application of ultra-wide-field fundus autofluorescence in early metastatic choroidal tumor screening. Int J Ophthalmol 2019;12(12):1978-1981.

Zhai Y, Zhu S, Li J, Yao K*. A Novel Human Congenital Cataract Mutation in EPHA2 Kinase Domain (p.G668D) Alters Receptor Stability and Function. Invest Ophthalmol Vis Sci. 2019 Nov 1;60(14):4717-4726. 

Ye Y, Wu M, Qiao Y, Xie T, Yu Y, Yao K*. Identification and preliminary functional analysis of two novel congenital cataract associated mutations of Cx46 and Cx50. Ophthalmic Genet. 2019 Oct;40(5):428-435. 

Yu X, Guo H, Liu X, Wang G, Min Y, Chen S, Han SS, Chang RT, Zhao X, Hsing A, Zhu S, Yao K*. Dry eye and sleep quality: a large community-based study in Hangzhou. Sleep. 2019 Jul 15. pii: zsz160. 

Lin Y, Lin J, Su Z, Chen Z, Yao K*. Characterization and Management of Late Postoperative Capsular Block Syndrome Following Phacoemulsification or Phacovitrectomy. Am J Ophthalmol. 2019 Aug; 204:19-25. 

Qin Z, Zhang L, Lyu D, Jiayong Li, Qiaomei Tang, Houfa Yin, Zhijian Chen, Ke Yao*, Qiuli Fu*. Opacification of lentoid bodies derived from human induced pluripotent stem cells is accelerated by hydrogen peroxide and involves protein aggregation. J Cell Physiol. 2019; 1–13.

Zhu Y, Chen X, Chen P, Xu W, Shentu X, Yu Y, Yao K*. Lens capsule-related complications of femtosecond laser-assisted capsulotomy versus manual capsulorhexis for white cataracts. J Cataract Refract Surg. 2019 Mar; 45(3):337-342. 

Yan C, Han Y, Yu Y, Wang W, Lyu D, Tang Y, Yao K*. Effects of lens extraction versus laser peripheral iridotomy on anterior segment morphology in primary angle closure suspect. Graefes Arch Clin Exp Ophthalmol. 2019 Jul;257(7):1473-1480. 

Xu JW, Yao K*, Xu ZK*. Nanomaterials with a photothermal effect for antibacterial activities: an overview. Nanoscale. 2019 Apr 23. 

Chen K, Lai K, Zhang X, Qin Z, Fu Q, Luo C, Jin X, Hu J, Liu S, Yao K*. Bromfenac Inhibits TGF-β1-Induced Fibrotic Effects in Human Pterygium and Conjunctival Fibroblasts. Invest Ophthalmol Vis Sci. 2019 Mar 1; 60(4):1156-1164. 

Zhang X, Yu Y, Zhang G, Zhou Y, Zhao G, Chen M, Wang Y, Zhu S, Zhang H8, Yao K9*. Performance of femtosecond laser-assisted cataract surgery in Chinese patients with cataract: a prospective, multicenter, registry study. BMC Ophthalmol. 2019 Mar 14;19(1):77. 

Mo Z, Fu Q, Lyu D, Zhang L, Qin Z, Tang Q, Yin H, Xu P, Wu L, Wang X, Lou X, Chen Z, Yao K*. Impacts of air pollution on dry eye disease among residents in Hangzhou, China: A case-crossover study. Environ Pollut. 2019 Mar; 246:183-189.

He C, Ye T, Teng W, Fang Z, Ruan WS, Liu G, Chen H, Sun J, Hui L, Sheng F, Pan D, Yang C, Zheng Y, Luo MB, Yao K, Wang B. Bioinspired Shear-Flow-Driven Layer-by-Layer in Situ Self-Assembly. ACS Nano. 2019 Feb 26;13(2):1910-1922. 

Qiao Y, Ping Y, Zhang H, Zhou B, Liu F, Yu Y, Xie T, Li W, Zhong D, Zhang Y, Yao K, Santos HA, Zhou M. Laser-Activatable CuS Nanodots to Treat Multidrug-Resistant Bacteria and Release Copper Ion to Accelerate Healing of Infected Chronic Nonhealing Wounds. ACS Appl Mater Interfaces. 2019 Jan 30;11(4):3809-3822. 

Jin HY, Wan T, Yu XN, Wu F, Yao K. Corneal higher-order aberrations of the anterior surface, posterior surface, and total cornea after small incision lenticule extraction (SMILE): high myopia versus mild to moderate myopia. BMC Ophthalmol. 2018 Nov 12;18(1):295. 

Lin YC, Shen ZR, Song XH, Liu X, Yao K*. Comparative transcriptomic analysis reveals adriamycin-induced apoptosis via p53 signaling pathway in retinal pigment epithelial cells. J Zhejiang Univ Sci B. 2018 Dec.; 19(12):895-909. 

Chen XJ, Hu LD, Yao K, Yan YB*. Lanosterol and 25-hydroxycholesterol dissociate crystallin aggregates isolated from cataractous human lens via different mechanisms. Biochemical and Biophysical Research Communications. 506 (2018) Nov. 868-873.

Jing Ai,* Jun-Hui Sun,* Ting Wan, Jian Ma,Lei Feng, Ke Yao*. Generation of an anti-angiogenic endothelial progenitor cell line via endostatin gene transfer. Mol Med Rep. 2018 Apr; 17(4): 5814-5820.

Jia Xu, Wei-Jie Zhao, Xiang-Jun Chen, Ke Yao*, Yong-Bin Yan **.  Introduction of an extra tryptophan fluorophore by cataract-associating mutations destabilizes bB2-crystallin and promotes aggregation. Biochemical and Biophysical Research Communications 504 (2018) 851-856.

Zhu S, Xi XB, Duan TL, Zhai Y, Li J, Yan YB, Yao K*. The cataract-causing mutation G75V promotes γS-crystallin aggregation by modifying and destabilizing the native structure. Int J Biol Macromol. 2018 Oct 1;117:807-814. 

Zhao J, Wu X, Wu D, Yu Y, Yu Y, Wang Y, Fu Q, Zhang J, Yao K*. Embryonic Surface Ectoderm-specific Mitofusin 2 Conditional Knockout Induces Congenital Cataracts in Mice. Sci Rep. 2018 Jan 24; 8(1):1522. 

Shen T, Zheng QQ, Shen J, Li QS, Song XH, Luo HB, Hong CY, Yao K*. Effects of Adipose-derived Mesenchymal Stem Cell Exosomes on Corneal Stromal Fibroblast Viability and Extracellular Matrix Synthesis. Chin Med J 2018; 131:704-12.

Zhu S, Qu N, Wang W, Zhu Y, Shentu X, Chen P, Xu W, Yao K*. Morphologic features and surgically induced astigmatism of femtosecond laser versus manual clear corneal incisions. J Cataract Refract Surg. 2017 Nov; 43(11):1430-1435. 

Jing Ai, Jun-Hui Sun, Jian Ma, Ke Yao*. Effects of lentivirus-mediated endostatin on endothelial progenitor cells. Oncotarget, 2017, Vol. 8, (No. 55), pp: 94431-94439.

Tang Y, Chen X, Zhang X, Tang Q, Liu S, Yao K*. Clinical evaluation of corneal changes after phacoemulsification in diabetic and non-diabeticcataract patients, a systematic review and meta-analysis. Sci Rep. 2017 Oct 26;7(1):14128. 

Jin HY, Wan T, Wu F, Yao K*. Comparison of visual results and higher-order aberrations after small incision lenticuleextraction (SMILE): high myopia vs. mild to moderate myopia. BMC Ophthalmol. 2017 Jul 6; 17(1):118. 

Qiuli Fu, Zhenwei Qin, Lifang Zhang, Danni Lyu, Qiaomei Tang, Houfa Yin, Zhijian Chen, Ke Yao* A New Long Noncoding RNA ALB Regulates Autophagy by Enhancing the Transformation of LC3BI to LC3BII during Human Lens Development. Molecular Therapy: Nucleic Acids Vol. 9 December 2017 207-217.

Fu Q, Mo Z, Lyu D, Zhang L, Qin Z, Tang Q, Yin H, Xu P, Wu L, Lou X, Chen Z, Yao K*. Air pollution and outpatient visits for conjunctivitis: A case-crossover study in Hangzhou, China Environ Pollut. 2017 Dec; 231(Pt 2):1344-1350. 

Chenqi Luo, Xinyi Chen, Hongchuan Jin*, Ke Yao*. The association between gout and cataract risk: A meta-analysis. PLoS One. 2017 Jun 29;12(6):e0180188. doi: 10.1371/journal.pone.0180188. eCollection 2017.

Qiaomei Tang, Chenqi Luo, Bing Lu, Qiuli Fu, Houfa Yin, Zhenwei Qin, Danni Lyu, Lifang Zhang, Zhi Fang, Yanan Zhu, Ke Yao*. Thermosensitive chitosan-based hydrogels releasing stromal cell derived factor-1 alpha recruit MSC for corneal epithelium regeneration. Acta Biomater. 2017 Oct 1; 61:101-113. 

Jin C, Chen X, Law A, Kang Y, Wang X, Xu W, Yao K. Different-sized incisions for phacoemulsification in age-related cataract. Cochrane Database of Systematic Reviews 2017, Issue 9. Art. No.: CD010510. 

Chenxi Fu, Naipin Chu, Xiaoning Yu, and Ke Yao*. Bimanual Microincision Cataract Surgery versus Coaxial Microincision Cataract Surgery: A Meta-Analysis of Randomized Controlled Trials and Cohort Studies. J Ophthalmol. 2017; 2017:3737603. 

Zhao WJ, Xu J, Chen XJ, Liu HH, Yao K*, Yan YB*  Effects of cataract-causing mutations W59C and W151C on βB2-crystallin structure, stability and folding  Int J Biol Macromol. 2017 May 19; 103:764-770.

Fu Q, Lyu D, Zhang L, Qin Z, Tang Q, Yin H, Lou X, Chen Z, Yao K*. Airborne particulate matter (PM2.5) triggers autophagy in human corneal epithelial cell line  Environ Pollut. 2017 Aug; 227:314-322.

Li J, Xia CH, Wang E, Yao K, Gong X. Screening, genetics, risk factors, and treatment of neonatal cataracts  Birth Defects Res. 2017 Jun 1;109(10):734-743.

Yueqiu Luo, Siyu Liu, Ke Yao. Transcriptome-wide Investigation ofmRNA/circRNA in miR-184 and Its r.57c > u Mutant Type Treatment of Human Lens Epithelial Cells  Molecular Therapy: Nucleic Acids Vol. 7 June 2017,71-80.

Zhai Y, Li J, Yu W, Zhu S, Yu Y, Wu M, Sun G, Gong X, Yao K*. Targeted Exome Sequencing of Congenital Cataracts Related Genes: Broadening the Mutation Spectrum and Genotype-Phenotype Correlations in 27 Chinese Han Families Sci Rep. 2017 Apr 27; 7(1):1219. 

Shen Z, Lin Y, Zhu Y, Liu X, Yan J, Yao K* Clinical comparison of patient outcomes following implantation of trifocal or bifocal intraocular lenses: a systematic review and meta-analysis  Sci Rep. 2017 Mar 28;7:45337. 

Xinyi Chen, MD, Yinhui Yu, MD, Xiaohui Song, MD, Yanan Zhu, MD, Wei Wang, MD, Ke Yao*, MD  Clinical outcomes of femtosecond laser–assisted cataract surgery versus conventional phacoemulsification surgery for hard nuclear cataracts  J Cataract Refract Surg 2017; 43:486–491.

Qiuli Fu, Zhenwei Qin, Xiuming Jin, Lifang Zhang,Zhijian Chen, Jiliang He,Junfeng Ji, Ke Yao. Generation of Functional Lentoid Bodies From Human Induced Pluripotent Stem Cells Derived From Urinary Cells  Invest Ophthalmol Vis Sci. 2017;58:517–527.

Zhu Y, Chen X, Chen P, Wu J, Hua H, Yao K*. The occurrence rate of acute-onset postoperative endophthalmitis after cataract surgery in Chinese small- and medium-scale departments of ophthalmology. Sci Rep. 2017 Jan 17; 7:40776. 

Xiaodan Huang*, Chenqi Luo, Lin Lin, Li Zhang, Heyi Li, Ke Yao*, Zhikang Xu. UV-assisted treatment on hydrophobic acrylic IOLs anterior surface with methacryloyloxyethyl phosphorylcholine: Reducing inflammation and maintaining low posterior capsular opacification properties. Materials Science and Engineering C 75 (2017) 1289-1298.

Wu MH, Yu YH, Hao QL, Gong XH, Yao K*. A novel splice site mutation of CRYBA3/A1 gene associated with congenital cataract in a Chinese family. Int J Ophthalmol. 2017 Jan 18;10(1):1-5. doi: 10.18240/ijo.2017.01.01. eCollection 2017.

Shen Z, Zhu Y, Song X, Yan J, Yao K*. Dry Eye after Small Incision Lenticule Extraction (SMILE) versus Femtosecond Laser-Assisted in Situ Keratomileusis (FS-LASIK) for Myopia: A Meta-Analysis. PLoS One. 2016 Dec 16;11(12):e0168081. doi: 10.1371/journal.pone.0168081. eCollection 2016.

Zhang L, Zhang K, Zhu YN, Wang QW, Yao K*. Case report of unilateral electric cataract with transmission electron microscopy image  Int J Ophthalmol. 2016 Apr 18; 9(4):636-7.

Kai Jin, Bo Li, Lixia Lou, Yufeng Xu, Xin Ye, Ke Yao, Juan Ye, Changyou Gao. In vivo vascularization of MSC-loaded porous hydroxyapatite constructs coated with VEGF-functionalized collagen/heparin multilayers  Sci Rep. 2016 Jan 22;6:19871. 

Fu Q, Qin Z, Yu J, Yu Y, Tang Q, Lyu D, Zhang L, Chen Z, Yao K* Effects of senescent lens epithelial cells on the severity of age-related cortical cataract in humans: A case-control study  Medicine (Baltimore). 2016 Jun; 95(25):e3869.

Chuan-bin Sun,*Yong-sheng You,*, Zhe Liu, Lin-yan Zheng, Pei-qing Chen, Ke Yao, An-quan Xue. Myopic Macular Retinoschisis in Teenagers: Clinical Characteristics and Spectral Domain Optical Coherence Tomography Findings Sci Rep. 2016 Jun 13;6:27952. 

Zhenwei Qin, Qiuli Fu, Lifang Zhang,Houfa Yin,Xiuming Jin,Qiaomei Tang, Danni Lyu, Ke Yao*.  Proliferative Effects of Histamine on Primary Human Pterygium Fibroblasts  Mediators of Inflammation Volume 2016, Article ID 9862496.

Jiaojie Zhou, Ke Yao,et al. Thioredoxin Binding Protein-2 Regulates Autophagy of Human Lens Epithelial Cells under Oxidative Stress via Inhibition of Akt Phosphorylation  Oxidative Medicine and Cellular Longevity Volume 2016, Article ID 4856431.

Kairan Lai, Chenqi Luo, Xiaobo Zhang, Panpan Ye, Yidong Zhang , Jiliang He , Ke Yao*. Regulation of angiogenin expression and epithelial-mesenchymal transition by HIF-1α signaling in hypoxic retinal pigment epithelial cells  Biochimica et Biophysica Acta 1862 (2016) 1594–1607.

Yu Y, Wu M, Chen X, Zhu Y, Gong X, Yao Ke, Identification and functional analysis of two novel connexin 50 mutations associated with autosome dominant congenital cataracts. Sci Rep. 2016 May 24; 6:26551.

Zeren Shen, Keda Shi, Yinhui Yu, Xiaoning Yu, Yuchen Lin, Ke Yao*  Small Incision Lenticule Extraction (SMILE) versus Femtosecond Laser-Assisted In Situ Keratomileusis (FS-LASIK) for Myopia: A Systematic Review and Meta-Analysis  PLoS One. 2016 Jul 1;11(7):e0158176. 

Yu YB, Zhu YN, Wang W, Zhang YD, Yu YH, Yao K. A comparable study of clinical and optical outcomes after 1.8, 2.0 mm microcoaxial and 3.0 mm coaxial cataract surgery  Int J Ophthalmol. 2016 Mar 18; 9(3):399-405.

Xinyi Chen, Kailin Chen, Jiliang He, Ke Yao*.  Comparing the Curative Effects between Femtosecond Laser-Assisted Cataract Surgery and Conventional Phacoemulsification Surgery: A Meta-Analysis. PLoS ONE 11(3): e0152088. 

Yinhui Yu, Xinyi Chen , Huixia Hua, Menghan Wu, Kairan Lai, Ke Yao*. Comparative outcomes of femtosecond laserassisted cataract surgery and manual phacoemusification: a six-month follow-up Clinical & Experimental Ophthalmology. Article first published online: 17 FEB 2016

Yinhui Yu, Huixia Hua, Menghan Wu, Yibo Yu, Wangshu Yu, Kairan Lai, Ke Yao*. Evaluation of dry eye after femtosecond laser–assisted cataract surgery J Cataract Refract Surg 2015; 41:2614–2623.

Liu X, Chen J, Liu Z, Li J, Yao K*, Wu Y. Potential therapeutic agents against retinal diseases caused by aberrant metabolism of retinoids. Invest Ophthalmol 2016; 57:1017–1030.

Gong L, Sun X, Ma Z, Wang Q, Xu X, Chen X, Shao Y, Yao K, Tang L, Gu Y, Yuan H, Chua WH, Chuan JC, Tong L. A randomised, parallel-group comparison study of diquafosol ophthalmic solution in patients with dry eye in China and Singapore. Br J Ophthalmol. 2015 Jul; 99(7):903-8.

Chen Z, Zhai Y, Zhang W, Teng Y, Yao K*. Single Nucleotide Polymorphisms of the Sirtuin 1 (SIRT1) Gene are Associated With age-Related Macular Degeneration in Chinese Han Individuals: A Case-Control Pilot Study. Medicine (Baltimore). 2015 Dec;94(49):e2238

Zhai Y, Wang W, Zhu YN, Li JY, Yu YH, Lai KR, Yao K*  A novel FBN1 missense mutation (p.C102Y) associated with ectopia lentis syndrome in a Chinese family  Int J Ophthalmol. 2015 Oct 18; 8(5):855-859.

Yinhui Yu, Peijin Qiu, Yanan Zhu, Jinyu Li, Menghan Wu, Buyi Zhang3 and Ke Yao*  A novel phenotype-genotype correlation with an Arg555Trp mutation of TGFBI gene in Thiel-Behnke corneal dystrophy in a Chinese pedigree  BMC Ophthalmology (2015) 15:131.

Wenting Ding, Weiling Ni, Huilian Chen, Jingqun Yuan, Xiaodan Huang, Zheng Zhang, Yao Wang, Yibo Yu, Ke Yao*. Comparison of Drug Concentrations in Human Aqueous Humor after the Administration of 0.3% Gatifloxacin Ophthalmic Gel, 0.3% Gatifloxacin and 0.5% Levofloxacin Ophthalmic Solutions. International Journal of Medical Sciences 2015; 12(6): 517-523.

Xu JW, Wang Y, Yang YF, Ye XY, Yao K*, Ji J, Xu ZK. Effects of quaternization on the morphological stability and antibacterial activity of electrospun poly(DMAEMA-co-AMA) nanofibers  Colloids Surf B Biointerfaces. 2015 Sep 1; 133:148-55.

Ke Yao*, Yongzhen Bao, Jian Ye, Yi Lu, Hongsheng Bi, Xin Tang, Yune Zhao, Jinsong Zhang, Jinling Yang  Efficacy of 1% carboxymethylcellulose sodium for treating dry eye after phacoemulsification: results from a multicenter, open-label, randomized, controlled study  BMC Ophthalmol. 2015; 15:28.

Wei Wang, Min Chen, Yao Wang, Ke Yao*  Bilateral capsule contraction syndrome-induced ciliary body detachment  J Cataract Refract Surg. 2015 Feb;41(2):468-70.

Jie Li,* Xianhui Cai*, Qingqing Xia, Ke Yao, Jingmeng Chen§, Yanli Zhang*, Hua Naranmandura, Xin Liu, and Yalin Wu, Involvement of Endoplasmic Reticulum Stress in All-Trans-Retinal-Induced Retinal Pigment Epithelium Degeneration TOXICOLOGICAL SCIENCES, 143(1), 2015, 196–208.

Suxia Qi, Zhi Fang, Danli Wang, Pablo Menendez, Ke Yao*, Junfeng Ji*  Concise review: Induced Pluripotency by Defined Factors: Prey of Oxidative Stress STEM CELLS 2015 May;33(5):1371-6.

Current Program

The role of Eph receptor-mediated membrane-cytoskeleton complex in cataract formation. Funding Source: General Program of National Natural Science Foundation of China.

In search of mechanism for congenital cataract using patient specific iPSCs and lentoid bodies disease models. Funding Source: National Key Program on R&D of Zhejiang Province.

Investigation of novel surgical techniques of important blinding eye diseases. Funding Source: National Key R&D Program of Zhejiang Province.

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