Department：Orthopedics
Medical School：Zhejiang University School of Medicine, China
Academic Rank：Chief Physician
Bone and soft tissue tumor, especially osteosarcoma; bone trauma, especially limb and pelvic fracture.
Advanced Worker Award, Zhejiang University School of Medicine, 2009
Member, Zhejiang Anti-Cancer Association
Prof. Yang's study is to investigate the effects of estrogen receptor β (ERβ) on osteosarcoma cells, and explore the regulatory mechanisms underlying this process.
ERβ can induce both apoptosis and autophagy in osteosarcoma cells. When autophagy was switched on in osteosarcoma cells, ERβ agonist DPN can activate NF-κB signaling pathway to prevent autophagic cell death and increase cell viability. DPN-induced autophagy served as a death mechanism in U2-OS cells. DPN-induced autophagy and apoptosis had synergistic effect on cell death of U2-OS cells, PI3K/Akt/mTOR pathway maybe regulate this effect.
Shen CC, Li H, Shi ZL, Tao HM, Yang ZM*. Current treatment of sacral giant cell tumour of bone: a review. Journal of International Medical Research. 2012, 40:415-425.
Yang ZM, Tao HM*, Ye ZM, Li WX, Lin N, Yang DS. Multivariate analysis of the prognosis of 37 patients with chondrosarcoma. Asian Pacific Journal of Cancer Prevention. 2012, 13:1171-1176.
Liu B, Qu LY, Yang ZM*, Tao HM. Cyclooxygenase-2 inhibitors induce anoikis in osteosarcoma via PI3K/Akt pathway. Medical Hypotheses. 2012, 79:98-100.
Yang ZM, Tao HM*, Ye ZM, Yang DS. Multicentric epithelioid angiosarcoma of bone: a case report and literature review. Orthopedics. 2012, 35:1293-1296.
Yang ZM，Jin LB*, Tao HM, Yang DS. Reconstruction of large tibial bone defects following osteosarcoma resection using bone transport distraction: A report of two cases. Oncology letters. 2016,12:1445-1447.
Menfei Yang, Bing Liu, Libin Jin, Huimin Tao, Zhengming Yang*. Estrogen receptor B exhibited anti-tumor effects on osteosarcoma cells by regulating integrin, IAP, NF-KB/BCL-2 and PI3K/Akt signal pathway. Journal of Bone Oncology. 2017, 9:15-20.
Zhengming Yang, Minfei Yang, Hiumin Tao*, Bing Liu, Libin Jin, Effect of 17B-estradiolon the migration ability of human osteosarcoma U2OS cells. Translational Cancer Research. 2018, 7(5):1221-1227.
Zhengming Yang, Huimin Tao*, Zhaoming Ye, Libin Jin, Nong Lin, Disheng Yang. Bone transport for reconstruction of large bone defects after tibial tumor resection: a report of five cases. Journal of International Medical Research. 2018, 46(8): 3219-3225.
Zhengming Yang, Menfei Yang , Wei Yu, Huimin Tao*.Molecular mechanisms of strogen receptor beta-induced apoptosis and autophagy in tumors: implication for treating osteosarcoma. Journal of nternational medical research. 2019,47(10):4644-4655.
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Zhejiang University School of Medicine
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