Yan Shigui, B.S.

Position:Honorary Chair of Orthopedics


Medical School:Zhejiang University School of Medicine, China

Academic Rank:Professor, Chief Physician


Clinical / Research Interests

Rheumatoid arthritis, ankylosing spondylitis, joint stiffness caused by late deformity, necrosis of the femoral head, advanced osteoarthritis, high innate dislocation of the hip, severe hip dysplasia, diagnosis and treatment of infections and previous hip surgery due to severe chronic hip deformity and other complex bone and joint diseases.

Professional Highlights

Zhejiang Scientific and Technological Progress Award, Second Prize, 2007

Scientific and Technological Progress Award, Health Commission of Zhejiang Province, First Prize, 2006 

Scientific and Technological Progress Award, Education Department of Zhejiang Province, First Prize, 2000 

Professional Appointments

Member, Orthopaedic Committee, Chinese Medical Association

Member, Osteoporosis and Bone Mineral Salt Committee, Chinese Medical Association

Chairman, Bone Mineral Salt Committee , Zhejiang Medical Association

Former Chairman, Orthopedics Committee, Zhejiang Medical Association 

Associate Editor, Chinese Journal of Orthopaedics

Editor, Journal of Surgery

Editorial Board, Journal of Orthopaedic Surgery

Education Experience

Research Summary

Basic research of bioactive bone cement, orthopedic prosthesis-related infections diagnosis and treatment, prevention and treatment of osteoporosis and three-dimensional finite element analysis of bone joints.


Yan SG*, Cai XZ, Yan WQ, Dai XS, Wu HB. Continuous wave ultrasound enhances vancomycin release and antimicrobial efficacy of antibiotic-loaded acrylic bone cement in vitro and in vivo. J Biomed Mater Res B Appl Biomater. 2007; 82(1): 57-64. 

Cai XZ, Yan SG*, Wu HB, He RX, Dai XS, Chen HX, Yan RJ, Zhao XH. Enhancement of Delayed Pulsed Wave Ultrasound on Local Pharmacokinetics and Pharmacodynamics of Vancomycin-Loaded Acrylic Bone Cement in Vivo. Antimicrob Agents Chemother. 2007; 51(9): 3199-204.

 Huang X, Yang DS, Yan WQ, Shi ZL, Feng J, Gao YB, Weng WJ, Yan SG*. Osteochondral repair using the combination of fibroblast growth factor and amorphous calcium phosphate/poly(L-lactic acid) hybrid materials. Biomaterials. 2007; 28(20): 3091-100.

 He RX, Yan SG*, Wu LD, Wang XH, Dai XS. Position of the prosthesis and the incidence of dislocation following total hip replacement. Chin Med J (Engl). 2007; 120(13): 1140-4.

Cai XZ, Chen XZ, Yan SG*. Routine or selective use of antibiotic cement for primary hip arthroplasty. Acta Orthop.2008; 79(6): 870-872.

Dai XS, Yu XZ, Wu LD, He RX, Wang XH, Yan SG*. Use of mid-vastus approach in less invasive primary total knee arthroplasty. Chin Med J (Engl).  2008; 21(9): 787-790.

Zhang P, Dai KR, Yan SG, Yan WQ, Zhang C, Chen DQ, Xu B, Xu ZW. Effects of naringin on the proliferation and osteogenic differentiation of human bone mesenchymal stem cell. Eur J Pharmacol. 2009; 607(1-3): 1-5.

Cai XZ, Chen XZ, Yan SG*. Cemented hemiarthroplasty confers less pain and better mobility than uncemented hemiarthroplasty. Clin Orthop Relat Res. 2009; 467(2): 582-584. 

Cai XZ, Chen XZ, Yan SG*, Ruan ZR, Yan RJ, Ji K, Xu J. Intermittent watt-level ultrasonication facilitates vancomycin release from therapeutic acrylic bone cement. J Biomed Mater Res B Appl Biomater. 2009; 90B(1): 11-17.

Lu Z, Lu Z, Zhu Y, Yan Z, Liu X, Yan SG, Shi GP. Enhanced hypertension prevalence in non-Han Chinese minorities from Xinjiang Province, China. Hypertens Res. 2009; 32(12): 1097-103.

Zhu FB, Cai XZ, Yan SG*, Zhu HX, Li R. The effects of local and systemic alendronate delivery on wear debris-induced osteolysis. J Orthop. Res. 2009,Jan 7. 

Lu ZS, Lu ZH, Lu H, Yan SG, Wang JA, Li L, You W. Association between hyperuricemia and hypertension in a Chinese population at a high risk of hypertension. Blood Press. 2009; 18(5): 268-72.

Wu HB, Yan SG*, Wu LD, He RX, Wang XH, Dai XS. Combined use of extensively porous-coated femoral components with onlay cortical strut allografts in revision of Vancouver B2 and B3 periprosthetic femoral fractures. Chinese Medical Journal. 2009; 122(21): 2612-2615.

Zhang H, Zhang L, Wang J, Ma Y, Zhang J, Mo F, Zhang W, Yan SG*, Yang G, Lin B. Proteomic Analysis of Bone Tissues of Patients with Osteonecrosis of the Femoral Head. OMICS. 2009; 13(6): 453-466.

Gao X, He RX, Yan SG. Total hip arthroplasty for patients with osteoarthritis secondary to hip pyogenic infection. Chinese Medical Journal. 2010; 123(2): 156-159.

Cai XZ, Jin AD, Yan SG*. Did local teicoplanin delivery systems inhibit or aggravate implant-related infection. Int. Orthop. 2010; 34(3): 453-4.

Zhao X, Yan SG*. Low-intensity pulsed ultrasound (LIPUS) therapy may enhance the negative effects of oxygen radicals in the acute phase of fracture. Med Hypotheses. 2010 Nov 8. 

Yan SG, Huang LY, Cai XZ. Low-intensity pulsed ultrasound: A potential non-invasive therapy for femoral head osteonecrosis. Med Hypotheses. 2010 Sep 6. 

Gao X, He RX, Yan SG, Wu LD. Dermatitis Associated With Chromium Following Total Knee Arthroplasty. J Arthroplasty. 2010; Jul 19. 

Cai YZ, Yan SG*. Development of ceramic-on-ceramic implants for total hip arthroplasty. Orthop. Surg. 2010; 2(3): 175-81.

Lin T, Wang C, Cai XZ, Zhao X, Shi MM, Ying ZM, Yuan FZ, Guo C, Yan SG*. Clinical Efficacy and Safety Differences Between Denosumab and Alendronate in Postmenopausal Women with Low Bone Mineral Density and Osteoporosis: A Meta-Analysis. Int J Clin Pract. 2011.

Lin T, Yan SG (First Co-author), Cai XZ, Ying ZM. Bisphosphonates for Periprosthetic Bone Loss after Joint Arthroplasty: a Meta-Analysis of Fourteen Randomized Controlled Trials. Osteoporosis Int. 2011.

Zhao X, Yan SG, Li H, Wu HB. Short reconstruction nail for intertrochanteric fracture: does it really fit Asian feature? Arch Orthop Trauma Surg. 2011; Aug 4.

Gao X, Wu QH, Chen WS, Chen QX, Xu K, Li FC, Yan SG. An unusual high-pressure injection injury involving the cervical spinal cord. J Bone Joint Surg Br. 2011; 93(8): 1140-2.

Zhao X, Yan SG*. The expression of the allocation concealment for randomised controlled trials needs to be improved. Injury. 2011; 42(4): 430-1.

Zhao X, Yan SG*. Low-intensity pulsed ultrasound (LIPUS) therapy may enhance the negative effects of oxygen radicals in the acute phase of fracture. Med Hypotheses. 2011; 76(2): 283-5.

Ying ZM, Lin T, Yan SG*. Low-intensity pulsed ultrasound therapy: a potential strategy to stimulate tendon-bone junction healing. Journal of Zhejiang University SCIENCE B. 2012; 13(12): 955-963.

Shi MM, Cai XZ, Lin T, Wang W, Yan SG*. Is There Really No Benefit of Vertebroplasty for Osteoporotic Vertebral Fractures? Clin Orthop Relat Res. 2012; 470(10):2785-99.

Xin ZF, Shen CC, Tao LJ, Yan SG, Wu HB. Gambogic acid inhibits invasion of osteosarcoma via upregulation of TIMP-1. Int J Mol Med . 2013; 31(1): 105-12.

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