Yan Min, M.D.

Position:Chair of Anesthesiology

Department:Anesthesiology

Medical School:Kiel University School of Medicine, Germany

Academic Rank:Chief Physician, Professor


Appointment

Clinical / Research Interests

Cardiovascular surgery anesthesia, difficult airway management, critical treatment of severe patients, and diagnosis and treatment of acute and chronic pain.

Professional Highlights

First Prize, Zhejiang Scientific and Technological Award (2016)

First Prize, Zhejiang Medical and Health Science and Technology Award (2016)

First Prize, Zhejiang Medical and Health Innovation Award (2008)

Professional Appointments

Member, American Society of Anesthesiologists, 2011.12-present

Member, International Association for the Study of Pain, 2015-present

Member, Chinese Society of Anesthesiology, Chinese Medical Association, 2018.11-present

Member, Chinese Association of Anesthesiologists, Chinese Medical Doctor Association

Member, Standing Committee of Chinese Association of Pain Physicians, Chinese Medical Doctor Association, 2020.12-2023.12

Reviewer, Journal of Pharmaceutical Sciences

Reviewer, Sciences Brain Research

Reviewer, Acta Pharmacologica Sinica

Education Experience

2002.12-2004.08 Ph.D. in Anesthesiology, Kiel University School of Medicine, Germany

1986.09- 1991.7 Bachelor of Medicine, Zhejiang University School of Medicine, China

Research Summary

Epigenetic regulation of the peripheral nervous system in chronic neuropathic pain.

Impact of combined 137 Cs with thermotherapy on tumor cells and red blood cells in perioperative  autotransfusion for patients with tumor.

Impact and mechanism of isorhamnetin on revascularization following ischemic brain injury in diabetic rats.

Investigation of an anti-infectious, subcutaneous pump for epidural analgesia postoperatively.

Rational transfusion in clinical practice: A retrospective multicenter study.

Role of mitochondrial permeablity transition pore and PI3K/AKI in perioperative cardioprotection of sevoflurane postcondition.


Publications

Lu Y, Chen Q, Zhang H, Huang M, Yao Y, Ming Y, Yan M, Yu Y, Yu L. Machine Learning Models of Postoperative Atrial Fibrillation Prediction After Cardiac Surgery. J Cardiothorac Vasc Anesth. 2022 Nov 25:S1053-0770(22)00846-1.

Luo G, Yao Y, Tao J, Wang T, Yan M. Causal association of sleep disturbances and low back pain: A bidirectional two-sample Mendelian randomization study. Front Neurosci. 2022 Dec 2;16:1074605.

Liu Y, Yu L, Che X, Yan M. Prolonged Continuous Theta Burst Stimulation to Demonstrate a Larger Analgesia as Well as Cortical Excitability Changes Dependent on the Context of a Pain Episode. Front Aging Neurosci. 2022 Jan 28;13:804362.

Ren J, Yu L, Lin J, Ma L, Gao DS, Sun N, Liu Y, Fang L, Cheng Z, Sun K, Yan M. Dimethyl itaconate inhibits neuroinflammation to alleviate chronic pain in mice. Neurochem Int. 2022 Mar;154:105296.

Zhang H, Zhu L, Gao DS, Liu Y, Zhang J, Yan M, Qian J, Xi W. Imaging the Deep Spinal Cord Microvascular Structure and Function with High-Speed NIR-II Fluorescence Microscopy. Small Methods. 2022 May 22:e2200155.

Wu Y, Wang C, Yu L, Qian W, Xing X, Zhang M, Yan M. Abnormal within- and cross-networks functional connectivity in different outcomes of herpes zoster patients. Brain Imaging Behav. 2022 Feb;16(1):366-378.

Wang YS, Chen DX, Yan M, Wu Z, Guo YQ, Li Q, Du L. Prediction of the severity of acute kidney injury after on-pump cardiac surgery. J Clin Anesth. 2022 Jun;78:110664.

Ren J, Lin J, Yu L, Yan M. Lysophosphatidylcholine: Potential Target for the Treatment of Chronic Pain. Int J Mol Sci. 2022 Jul 27;23(15):8274.

Peng D, Yan M, Liu T, Yang K, Ma Y, Hu X, Ying G, Zhu Y. Prognostic Factors and Treatments Efficacy in Spontaneous Spinal Epidural Hematoma: A Multicenter Retrospective Study. Neurology. 2022 Aug 23;99(8):e843-e850.

Yang J, Tang L, Zhang F, Yang T, Lu T, Sun K, Sun N, Ren J, Yan M. Sevoflurane preconditioning promotes mesenchymal stem cells to relieve myocardial ischemia/reperfusion injury via TRPC6-induced angiogenesis. Stem Cell Res Ther. 2021 Nov 22;12(1):584.

Sun N, Yu L, Gao Y, Ma L, Ren J, Liu Y, Gao DS, Xie C, Wu Y, Wang L, Hong J, Yan M. MeCP2 Epigenetic Silencing of Oprm1 Gene in Primary Sensory Neurons Under Neuropathic Pain Conditions. Frontiers in neuroscience. 2021 Nov 5;15:743207.

Ma L, Yu L, Jiang BC, Wang J, Guo X, Huang Y, Ren J, Sun N, Gao DS, Ding H, Lu J, Zhou H, Zou L, Gao Y, Wang L, Sun K, Ming Y, Meng Z, Tao YX, Yan M. ZNF382 controls mouse neuropathic pain via silencer-based epigenetic inhibition of Cxcl13 in DRG neurons. The Journal of experimental medicine. 2021 Dec 6;218(12):e20210920.

Wu Y, Wang C, Yan M, et al. Abnormal within- and cross-networks functional connectivity in different outcomes of herpes zoster patients. Brain Imaging Behav 2021 Sep 21. doi: 10.1007/s11682-021-00510-y.

Jiang NJi WYan M. Assessment and Management of Pain in Patients with Osteoporotic Fragility Fracture. Pain Res Manag. 2021 Aug 7;2021:9856174. doi: 10.1155/2021/9856174. eCollection 2021.

Zhou L, Liu X, Yan M, et al. Postoperative Nadir Hemoglobin and Adverse Outcomes in Patients Undergoing On-Pump Cardiac Operation. Ann Thorac Surg. Ann Thorac Surg. 2021 Sep;112(3):708-716. doi: 10.1016/j.athoracsur.2021.01.016. Epub 2021 Jan 21.

Yan M, Wang M, Al-Hakim L. Barriers to reporting near misses and adverse events among professionals performing laparoscopic surgeries: a mixed methodology approach. Surg Endosc. Surg Endosc. 2021 Jan 4. doi: 10.1007/s00464-020-08215-x. Online ahead of print.

Liu YM, Feng Y, Yan M, et al. Chinese Association for the Study of Pain: Expert consensus on chronic postsurgical pain. World J Clin Cases. 2021;9(9):2090-2099.

Huang D, Liu YQ, Yan M, et al. Expert consensus of Chinese Association for the Study of Pain on the non-opioid analgesics for chronic musculoskeletal pain. World J Clin Cases. 2021;9(9):2068-2076.

Zhou ZF, Zhai W, Yan M, et al. Comparison of the in-vivo effect of two tranexamic acid doses on fibrinolysis parameters in adults undergoing valvular cardiac surgery with cardiopulmonary bypass - a pilot investigation. BMC Anesthesiol. 2021;21(1):33.

Xia C, Zhao Z, Yu L, Yan M. The role of the central histaminergic system in emergence from propofol anesthesia in rats model. Ann Palliat Med. 2021;10(6):6067-6078.

Wang L, Zhang W, Yan M, et al. Cholinergic-Induced Specific Oscillations in the Medial Prefrontal Cortex to Reverse Propofol Anesthesia. Front Neurosci. 2021;15:664410.

Ma L, Huang Y, Yan M, et al. MMP24 Contributes to Neuropathic Pain in an FTO-Dependent Manner in the Spinal Cord Neurons. Front Pharmacol. 2021;12:673831.

Yao Y, Cifuentes J, Zheng B, Yan M. The appropriate division of data in training of computers to predict physicians' decision on blood transfusions: a reply to Dr. Sander de. J Transl Med

Cifuentes J, Yao Y, Yan M, Zheng B. Blood transfusion prediction using restricted Boltzmann machines. Comput Methods Biomech Biomed Engin 23:510-517.2020

Dai QX, Huang LP, Mo YC, Yan M, et al. Role of spinal adenosine A1 receptors in the analgesic effect of electroacupuncture in a rat model of neuropathic pain. J Int Med Res 48:300060519883748.2020

Dong H, Zhang F, Chen J, Yan M, et al. Evaluating Propofol Concentration in Blood From Exhaled Gas Using a Breathing-Related Partition Coefficient. Anesth Analg 130:958-966.2020

Wu Y, Wang C, Qian W, Yan M, et al. Disrupted default mode network dynamics in recuperative patients of herpes zoster pain. CNS Neurosci Ther 26:1278-1287.2020

Xie C, Sun N, Sun K, Yan M, et al. Lung ultrasound and diaphragmatic excursion assessment for evaluating perioperative atelectasis and aeration loss during video-assisted thoracic surgery: a feasibility study. Ann Palliat Med 9:1506-1517.2020b

He W, You Y-Y, Sun K, Yan M et al. Admission delay is associated with worse surgical outcomes for elderly hip fracture patients: A retrospective observational study. World J Emerg Med 2020, 11(1):27-32.

Ming YLiu J,Zhang FYan M et al. Transfusion of Red Blood Cells, Fresh Frozen Plasma, or Platelets Is Associated With Mortality and Infection After Cardiac Surgery in a Dose-Dependent Manner. Anesth Analg 2020, 130(2):488-497.

Ren K-dPu Z-X Yan MWang J-A et al. The first two cases of transcatheter mitral valve repair with ARTO system in Asia. World J Emerg Med 2020, 11(1):33-36

Sun K, Liu D, Chen J, Yan M et al. Moderate-severe postoperative pain in patients undergoing video-assisted thoracoscopic surgery: A retrospective study. Sci Rep 2020, 10(1):795.

Sun KWang YYan MXia VW: Pretransplant left ventricular hypertrophy in association with postoperative myocardial injury in liver transplantation. Clin Transplant 2020, 34(5):e13847.

Wang H, Dong P, Yan M, Li X-M et al. Incerta-thalamic Circuit Controls Nocifensive Behavior via Cannabinoid Type 1 Receptors. Neuron 2020.1073538-551.E7

Wang X-Q, Xie W-Y, Yan M, Tian J et al: Effects of general anesthesia versus local anesthesia in primary hepatocellular carcinoma patients presenting for thermal ablation surgery: a multiple center retrospective cohort study with propensity score matching. Ann Transl Med 2020, 8(6):277.

Xing X-F, Bai Y, Sun K, Yan M et al. Identification of Candidate Genes Associated with Postherpetic Neuralgia Susceptibility. Pain Physician 2020, 23(3):E281-E288.

Xing X-F, Bai Y, Sun K, Yan M. Single nucleotide polymorphisms associated with postoperative inadequate analgesia after single-port VATS in Chinese population. BMC anesthesiology 2020, 20(1):38.

Xing X-F, Sun K, Yan M. Delayed Initiation of Supplemental Pain Management is Associated with Postherpetic Neuralgia: A Retrospective Study. Pain Physician 2020, 23(1):65-72.

Yu J, Wang W-N, Yan M, Zhang J-H Ezetimibe Attenuates Oxidative Stress and Neuroinflammation via the AMPK/Nrf2/TXNIP Pathway after MCAO in Rats. Oxid Med Cell Longev 2020, 2020:4717258

Yao Y, Cifuentes J, Zheng B, Yan M. Computer algorithm can match physicians' decisions about blood transfusions. J Transl Med. 2019. 17(1): 340.

Yu S, Sun K, Xing X, Yan M et al. Fan Therapy for the Relief of Dyspnea in Adults with Advanced Disease and Terminal Illness: A Meta-Analysis of Randomized Controlled Trials. J Palliat Med. 2019.

Yu X, Guo H, Yan M Liu X, et al. Dry eye and sleep quality: a large community-based study in Hangzhou. Sleep. 2019. 42(11).

Sun K, Wang Y, Yan M, Xia VW. Mild Preoperative Systolic Dysfunction Associated With the Use of Intraoperative Vasopressors but Not Postoperative Survival in Liver Transplantation. Transplant Proc. 2019. 51(6): 1892-1894.

Wang LH;Pu ZX;Kong MJ;Jiang JB;Ren KD;Gao F;Lin XP;Yu L;He W;Yan M;Liu XB;Wang JAang LH, Pu ZX, Kong MJ, et al.. The first four cases of successful NeoChord procedure in mainland China. World J Emerg Med. 2019. 10(3): 133-137.

Bai Y;Sun K;Xing X;Zhang F;Sun N;Gao Y;Zhu L;Yao J;Fan J;Yan M. Postoperative analgesic effect of hydromorphone in patients undergoing single-port video-assisted thoracoscopic surgery: a randomized controlled trial. J Pain Res. 2019. 12: 1091-1101.

Dong H;Zhang F;Chen J;Yu Q;Zhong Y;Liu J;Yan M. Evaluating Propofol Concentration in Blood From Exhaled Gas Using a Breathing-Related Partition Coefficient. Anesth Analg. 2019 .

Yao YY, Zhou QH, Yu LN, Yan M. Additional femoral nerve block analgesia does not reduce the chronic pain after total knee arthroplasty: A retrospective study in patients with knee osteoarthritis. Medicine (Baltimore). 2019. 98(13): e14991.

Li J, Kong XX, Zhou JJ, et al. Fast-track multidisciplinary treatment versus conventional treatment for colorectal cancer: a multicenter, open-label randomized controlled study. BMC Cancer. 2019. 19(1): 988. 

Current Program

ZNF382 controls mouse neuropathic pain via silencer-based epigenetic inhibition of Cxcl13 in DRG neurons. National Natural Science Foundation of China (82071227), 2021.01-2024.12

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