Yan Feng, M.D., Ph.D.

Department:Neurosurgery

Medical School:Zhejiang University School of Medicine, China

Academic Rank:Chief Physician


Appointment

Clinical / Research Interests

Traumatic brain injury, brain tumor, trigeminal neuralgia, facial spasm.

Professional Highlights

Clinical fellowship, University of California Los Angeles

Professional Appointments

Secretary General, Neurosurgery Branch, Zhejiang Medical Association, 2018-present

Secretary General, Neurosurgery Branch, Zhejiang Provincial Integrative Medicine Association, 2016-present 

Member, Zhejiang Stroke Association, 2018-present


Education Experience

Research Summary

Dr. Yan is engaged in the studies on the pathogenesis and therapeutic approaches for subarachnoid hemorrhage, intracranial hemorrhage and glioma. Dr. Yan has undertaken 4 projects supported by national and provincial foundation.

Publications

Sun C, Dou Z, Wu J, Jiang B, Iranmanesh Y, Yu X, Li J, Zhou H, Zhong C, Peng Y, Zhuang J, Yu Q, Wu X, Yan F, Xie Q, Chen G. The Preferred Locations of Meningioma According to Different Biological Characteristics Based on Voxel-Wise Analysis. Front Oncol. 2020 Aug 21;10:1412. 

Zhuang J, Peng Y, Gu C, Chen H, Lin Z, Zhou H, Wu X, Li J, Yu X, Cao Y, Zeng H, Fu X, Xu C, Huang P, Cao S, Wang C, Yan F, Chen G. Wogonin Accelerates Hematoma Clearance and Improves Neurological Outcome via the PPAR-γ Pathway After Intracerebral Hemorrhage. Transl Stroke Res. 2020 Sep 12. 

Peng Y, Zhuang J, Ying G, Zeng H, Zhou H, Cao Y, Chen H, Xu C, Fu X, Xu H, Li J, Cao S, Chen J, Gu C, Yan F, Chen G. Stimulator of IFN genes mediates neuroinflammatory injury by suppressing AMPK signal in experimental subarachnoid hemorrhage. J Neuroinflammation. 2020 May 25;17(1):165.

Lin YH, Guo L, Yan F, Dou ZQ, Yu Q, Chen G. Long non-coding RNA HOTAIRM1 promotes proliferation and inhibits apoptosis of glioma cells by regulating the miR-873-5p/ZEB2 axis. Chin Med J (Engl). 2020 Jan 20;133(2):174-182. 

Ruan W, Hu J, Zhou H, Li Y, Xu C, Luo Y, Chen T, Xu B, Yan F, Chen G. Intranasal wnt-3a alleviates neuronal apoptosis in early brain injury post subarachnoid hemorrhage via the regulation of wnt target PPAN mediated by the moonlighting role of aldolase C. Neurochem Int. 2020 Mar;134:104656.

Dou Z, Yu Q, Wang G, Wu S, Reis C, Ruan W, Yan F, Chen G. Circular RNA expression profiles alter significantly after intracerebral hemorrhage in rats. Brain Res. 2020 Jan 1;1726:146490. 

Gao L, Zhang Z, Xu W, Li T, Ying G, Qin B, Li J, Zheng J, Zhao T, Yan F, Zhu Y, Chen G. Natrium Benzoate Alleviates Neuronal Apoptosis via the DJ-1-Related Anti-oxidative Stress Pathway Involving Akt Phosphorylation in a Rat Model of Traumatic Spinal Cord Injury. Front Mol Neurosci. 2019 Feb 22;12:42. 

Li T, Xu W, Gao L, Guan G, Zhang Z, He P, Xu H, Fan L, Yan F, Chen G.Mesencephalic astrocyte-derived neurotrophic factor affords neuroprotection to early brain injury induced by subarachnoid hemorrhage via activating Akt-dependent prosurvival pathway and defending blood-brain barrier integrity. FASEB
J. 2019 Feb;33(2):1727-1741. 

Chen T, Pan H, Li J, Xu H, Jin H, Qian C, Yan F, Chen J, Wang C, Chen J, Wang L, Chen G. Inhibiting of RIPK3 attenuates early brain injury following subarachnoid hemorrhage: Possibly through alleviating necroptosis. Biomed Pharmacother. 2018 Nov;107:563-570. 

Gao L, Xu W, Li T, Chen J, Shao A, Yan F, Chen G. Stem Cell Therapy: A Promising Therapeutic Method for Intracerebral Hemorrhage. Cell Transplant. 2018 Dec;27(12):1809-1824. 

Gao L, Xu W, Li T, Yu X, Cao S, Xu H, Yan F, Chen G. Accuracy of magnetic resonance venography in diagnosing cerebral venous sinus thrombosis. Thromb Res. 2018 Jul;167:64-73. 

Gao L, Xu W, Fan S, Li T, Zhao T, Ying G, Zheng J, Li J, Zhang Z, Yan F, Zhu Y, Chen G. MANF attenuates neuronal apoptosis and promotes behavioral recovery via Akt/MDM-2/p53 pathway after traumatic spinal cord injury in rats. Biofactors. 2018 May 24. 

Fan LF, He PY, Peng YC, Du QH, Ma YJ, Jin JX, Xu HZ, Li JR, Wang ZJ, Cao SL, Li T, Yan F, Gu C, Wang L, Chen G. Mdivi-1 ameliorates early brain injury after subarachnoid hemorrhage via the suppression of inflammation-related blood-brain barrier disruption and endoplasmic reticulum stress-based apoptosis. Free Radic
Biol Med. 2017 Nov;112:336-349.

Li JR, Xu HZ, Nie S, Peng YC, Fan LF, Wang ZJ, Wu C, Yan F, Chen JY, Gu C, Wang C, Chen JS, Wang L, Chen G. Fluoxetine-enhanced autophagy ameliorates early brain injury via inhibition of NLRP3 inflammasome activation following subrachnoid hemorrhage in rats. J Neuroinflammation. 2017 Sep 13;14(1):186.

Yan F, Cao S, Li J, Dixon B, Yu X, Chen J, Gu C, Lin W, Chen G. Pharmacological Inhibition of PERK Attenuates Early Brain Injury After Subarachnoid Hemorrhage in Rats Through the Activation of Akt. Mol Neurobiol, 2017. 54(3): p. 1808-1817.

Yan F, Tan X, Wan W, Dixon BJ, Fan R, Enkhjargal B, Li Q, Zhang J, Chen G, Zhang JH. ErbB4 protects against neuronal apoptosis via activation of YAP/PIK3CB signaling pathway in a rat model of subarachnoid hemorrhage. Exp Neurol, 2017. 297: p. 92-100. 

Li JR, Xu HZ, Nie S, Peng YC, Fan LF, Wang ZJ, Wu C, Yan F, Chen JY, Gu C, Wang C, Chen JS, Wang L, Chen G. Fluoxetine-enhanced autophagy ameliorates early brain injury via inhibition of NLRP3 inflammasome activation following subrachnoid hemorrhage in rats. J Neuroinflammation, 2017. 14(1): p. 186. 

Cao S, Shrestha S, Li J, Yu X, Chen J, Yan F, Ying G, Gu C, Wang L, Chen G. Melatonin-mediated mitophagy protects against early brain injury after subarachnoid hemorrhage through inhibition of NLRP3 inflammasome activation. Sci Rep, 2017. 7(1): p. 2417. 

Ying GY, Jing CH, Li JR, Wu C, Yan F, Chen JY, Wang L, Dixon BJ, Chen G. Neuroprotective Effects of Valproic Acid on Blood-Brain Barrier Disruption and Apoptosis-Related Early Brain Injury in Rats Subjected to Subarachnoid Hemorrhage Are Modulated by Heat Shock Protein 70/Matrix Metalloproteinases and Heat Shock Protein 70/AKT Pathways. Neurosurgery, 2016. 79(2): p. 286-95.

Yan F, Li J, Chen J, Hu Q, Gu C, Lin W, Chen G. Endoplasmic reticulum stress is associated with neuroprotection against apoptosis via autophagy activation in a rat model of subarachnoid hemorrhage. Neurosci Lett, 2014. 563: p. 160-5. 

Li J, Yan F, Chen G. Reactive oxygen species and NLRP3 inflammasome activation. Ann Neurol, 2014. 75(6): p. 972. 

Chen J, Wang L, Wu C, Hu Q, Gu C, Yan F, Li J, Yan W, Chen G. Melatonin- enhanced autophagy protects against neural apoptosis via a mitochondrial pathway in early brain injury following a subarachnoid hemorrhage. J Pineal Res, 2014. 56(1): p. 12-9. 

Yan F, Hu Q, Chen J, Wu C, Gu C, Chen G. Progesterone attenuates early brain injury after subarachnoid hemorrhage in rats. Neurosci Lett, 2013. 543: p. 163-7. 

Current Program

The mechanism of Circular RNA targeting endoplasmic reticulum stress and mediate early brain injury afer subarachnoid hemorrhage. Funding Source: National Natural Science Foundation of China.

The mechanism and role of endoplasmic reticulum stress mediated autophagy in early brain injury afer subarachnoid hemorrhag. Funding Source: National Natural Science Foundation of China.

The mechanism of exosomes mediated by autophagy in early brain injury afer subarachnoid hemorrhag. Funding Source: Natural Science Foundation of Zhejiang.

The mechanism of HIF-1a mediated by thrombin in early brain injury afer subarachnoid hemorrhag. Funding Source: Natural Science Foundation of Zhejiang.


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