Xue Deting, M.D.

Department:Orthopedics

Medical School:Zhejiang University School of Medicine, China

Academic Rank:Associate Chief Physician


Appointment

Clinical / Research Interests

Orthopedic trauma, fracture, osteomyelitis, elbow illness.

Professional Highlights

Professional Appointments

Education Experience

Research Summary

Dr. Xu's research mainly focuses on the osteogenesis of mesenchymal stem cells and bone tissue engineering.

Publications

Xue D, Chen E, Zhong H, Zhang W, Wang S, Joomun MU, Yao T, Tan Y, Lin S, ZhengQ, Pan Z. Immunomodulatory properties of graphene oxide for osteogenesis and angiogenesis. Int J Nanomedicine. 2018 Sep 26;13:5799-5810. 

Hang K, Ye C, Chen E, Zhang W, Xue D, Pan Z. Role of the heat shock protein family in bone metabolism. Cell Stress Chaperones. 2018 Nov;23(6):1153-1164. 

Chen E, Liu G, Zhou X, Zhang W, Wang C, Hu D, Xue D, Pan Z.Concentration-dependent, dual roles of IL-10 in the osteogenesis of human BMSCs via P38/MAPK and NF-κB signaling pathways. FASEB J. 2018 Sep;32(9):4917-4929. 

Chen EEM, Zhang W, Ye CCY, Gao X, Jiang LLJ, Zhao TTF, Pan ZZJ, Xue DDT. Knockdown of SIRT7 enhances the osteogenic differentiation of human bone marrow mesenchymal stem cells partly via activation of the Wnt/β-catenin signaling pathway. Cell Death Dis. 2017 Sep 7;8(9):e3042. 

Xue D, Chen E, Zhang W, Gao X, Wang S, Zheng Q, Pan Z, Li H, Liu L. The role of hesperetin on osteogenesis of human mesenchymal stem cells and its function in bone regeneration. Oncotarget. 2017 Mar 28;8(13):21031-21043. 

Xue D, Zhang W, Chen E, Gao X, Liu L, Ye C, Tan Y, Pan Z, Li H. Local delivery of HMGB1 in gelatin sponge scaffolds combined with mesenchymal stem cell sheets to accelerate fracture healing. Oncotarget. 2017 Jun 27;8(26):42098-42115. 

Xue D, Yu J, Zheng Q, Feng G, Li W, Pan Z, Wang J, Li H. The treatment strategies of intertrochanteric fractures nonunion: An experience of 23 nonunion patients. Injury. 2017 Mar;48(3):708-714. 

Xue D, Chen Q, Chen G, Zhuo W, Li F. Posterior arthrodesis of C1-C3 for the stabilization of multiple unstable upper cervical fractures with spinal cord compromise: A case report and literature review. Medicine (Baltimore). 2017 Jan;96(1):e5841. 

Xue D, Li F, Chen G, Yan S, Pan Z. Do bisphosphonates affect bone healing? A meta-analysis of randomized controlled trials. J Orthop Surg Res. 2014 Jun 5;9:45. 

Xue D, Zheng Q, Li H, Qian S, Zhang B, Pan Z. Selective COX-2 inhibitor versus nonselective COX-1 and COX-2 inhibitor in the prevention of heterotopic ossification after total hip arthroplasty: a meta-analysis of randomised trials. Int Orthop. 2011 Jan;35(1):3-8. 

Xue D, Zheng Q, Zong C, Li Q, Li H, Qian S, Zhang B, Yu L, Pan Z.Osteochondral repair using porous poly(lactide-co-glycolide)/nano-hydroxyapatite hybrid scaffolds with undifferentiated mesenchymal stem cells in a rat model. J Biomed Mater Res A. 2010 Jul;94(1):259-70. 

Xue D, Zheng Q, Li H, Qian S, Zhang B, Pan Z. Reamed and undreamed intramedullary nailing for the treatment of open and closed tibial fractures: a subgroup analysis of randomised trials. Int Orthop. 2010 Dec;34(8):1307-13. 

Xue D, Zheng Q, Pan Z. Vibration may be a potential non-pharmacological treatment of osteoarthritis. Med Hypotheses. 2009 May;72(5):612. 


Current Program

Mechanisms of MFG-E8 in promoting bone healing in the microenvironment of fracture hematoma based on GSK3β / Rac1 / NF-κB pathways. Funding Source: National Natural Science Foundation of China.

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