Xu Wen, M.D., Ph.D.

Position:Vice Chair of Ophthalmology


Medical School:Zhejiang University School of Medicine, China

Academic Rank:Chief Physician


Clinical / Research Interests

Complicated cataract and intraocular lens surgery, intraocular contact lens implantation for correction of high myopia, combined surgery of anterior segment.

Professional Highlights

State Scientific and Technological Progress Award, Second Prize, 2019

Zhejiang Scientific and Technological Progress Award, First Prize, 2019

State Scientific and Technological Progress Award, Second Prize, 2007

Zhejiang Scientific and Technological Progress Award, First Prize, 2007

Zhejiang Provincial Science and Technology Innovation in Medicine and Health Award, First Prize, 2006

Zhejiang Provincial Science and Technology Innovation in Medicine and Health Award, First Prize, 2003

Zhejiang Scientific and Technological Progress Award, First Prize, 2003

Scientific and Technological Progress Award of Ministry of Education of China, Second Prize, 2000

Zhejiang Scientific and Technological Progress Award, Second Prize, 1999

Health Commision of Zhejiang Province Scientific and Technological Progress Award, Second Prize, 1999

Professional Appointments

Standing Committee Member, China Ophthalmologist Association, Chinese Medical Doctor Association

Secretary, Cataract Group, Chinese Society of Ophthalmology ,Chinese Medical Association

Committee Member, Ophthalmology Branch, China Medical Women's Association

Standing Board Member, Zhejiang Medical Association

Vice Chair, Chinese Society of Ophthalmology, Zhejiang Medical Association

Vice Chair and General Secretary, Zhejiang Ophthalmologist Association, Zhejiang Medical Doctor Association

Board Member, Zhejiang Aging Development Foundation

Education Experience

Research Summary


Xingdi Wu, Xiang Chen, Yajuan Ma, Xueqi Lin, Xuewen Yu, Suhong He, Chenqi Luo, Wen Xu*. Analysis of tear inflammatory molecules and clinical correlations in evaporative dry eye disease caused by meibomian gland dysfunction. Int Ophthalmol 2020:6.

Suhong He, Xiang Chen, Xingdi Wu, Yajuan Ma, Xuewen Yu, Wen Xu*. Early-stage clinical outcomes and rotational stability of TECNIS toric intraocular lens implantation in cataract cases with long axial length. BMC Ophthalmol (2020) 20: 204. 

Xi Li, Xiang Chen, Suhong He, Wen Xu*. Effect of 1.8-mm steep-axis clear corneal incision on the posterior corneal astigmatism in candidates for toric IOL implantation. BMC Ophthalmol (2020) 20:187.

Yajuan Ma, Xingdi Wu, Shuang Ni, Xiang Chen, Suhong He, Wen Xu*. The diagnosis and phacoemulsification in combination with intracular lens implantation for an Axenfeld-Rieger Syndrome patient with small cornea: A case report. BMC Ophthalmol (2020) 20:148. 

Li SY, Li X, He S, Zheng Q, Chen X, Wu X, Xu W*. Early postoperative rotational stability and its related factors of a single-piece acrylic toric intraocular lens. Eye (Lond). 2019 Jul 12; 34:474-479.

Ni S, Wang W, Chen X, Wu X, et al. Clinical observation of a novel technique: transscleral suture fixation of a foldable 3 - looped haptics one - piece posterior chamber intraocular lens implantation through scleral pockets with intact conjunctiva. BMC Ophthalmol 2019 May 9; 19(1):105.

He FY, Liu J, Ye P, Wu J, Liang G, Xu W*. Biophysical and microstructural changes of swelling cornea caused by endothelial cells damage. 2019 Aug 19; 68(5): 827-833.

Wu J, Liang GL, Zheng QY, He FY, Liu J, Xu W*. Fusion Phaco complex phacoemulsification through a coaxial 2.2 mm micro-incision: a clinical study. Int J Clin Exp Med 2018; 11(9):9931-9940.

Wang W, Ni S, Li, X, Chen X, Zhu YN, Xu W*. Femtosecond laser-assisted cataract surgery with implantation of a diffractive trifocal intraocular lens after laser in situ keratomileusis: a case report. BMC Ophthalmology 2018.

Li X, Ni S, Li SY, Zheng QY, Wu J, Liang GL, Xu W*. Comparison of three intraocular lens implantation procedures for aphakic eyes with insufficient capsular support: a network meta -analysis. Am J Ophthalmol 2018; 192:10-19.

Zhu S, Qu N, Wang W, Zhu Y, Shentu X, Chen P, Xu W, Yao K*. Morphologic features and surgically induced astigmatism of femtosecond laser versus manual clear corneal incisions. J Cataract Refract Surg. 2017 Nov;43(11):1430-1435.

Jin C, Chen X, Law A, Kang Y, Wang X, Xu W, Yao K*. Different-sized incisions for phacoemulsification in age-related cataract. Cochrane Database Syst Rev. 2017 Sep 20;9: CD010510. doi: 10.1002/14651858.CD010510.pub2.

Liu J, Xu JH, Xu W, Liang GL, Lou JX, Wang Y, Wen JQ, Cao YB*. Bevacizumab as adjuvant therapy in the management of pterygium: a systematic review and Meta-analysis. Int J Ophthalmol. 2017 Jul 18;10(7):1126-1133.

Wu Jing, Liang Guanlu, Zheng Qianyin, Li Shuyi, He Fengying, Xu Wen*. Comparison between iris-claw intraocular lens and scleral-fixated posterior chamber intraocular lens implantations in correcting aphakia: A meta-analysis. Invest Ophthalmol Vis Sci. 2017 July; 58:3530-3536.

Ye Panpan, He Fengying, Shi Junting, Liu Jian, Liang Guanlu, Wu Jing, Xu Wen*. Artisan iris-fixated intraocular lens implantation in combination with pupilloplasty ---- Correction of aphakia with pathologically large pupil and insufficient capsular support. Can J Ophthalmol. 2017;52(2):155-60.

Zheng Qianyin, Xu Wen*, et al. Preoperative biometric parameters predict the vault after ICL implantation: A retrospective clinical study. Ophthalmic Res. 2016;56(4):215-21.

Liu Jian, Ye Panpan, Su Zhaoan, Lin Kana, He Fengying, Xu Wen*. Suppression of choroidal neovascularization by Endostar in rats. Molecular Medicine Reports. 2015 May;11(5):3621-5.

Lin Kana, Ye Panpan, Liu Jian, He Fengying, Xu Wen*. Endostar inhibits hypoxia- induced cell proliferation and migration via HIF-1α/VEGF pathway in vitro. Molecular Medicine Reports. 2015 May;11(5):3780-5.

Liang Guanlu, Wu Jing, Shi Junting, Liu Jian, He Fengying, Xu Wen*. Implantable Collamer Lens versus iris-fixed phakic intraocular lens implantation to correct myopia: a meta-analysis. Plos ONE. 2014 Aug 12; 9(8): e104649. doi: 10.1371/journal.pone.0104649. eCollection 2014.

Jin X*, Zhao Y, Tong N, Xu W. Use of crawford tube for chronic suppurative lacrimal canaliculitis. Ophthal Plast Reconstr Surg. 2014 May-Jun;30(3):229-32.

Liu Jian, Ye Panpan, Xu Wen*. Current choroid neovascularization treatment. Ophthalmologica. 2013;230(2):55-61.

Ye P, Liu J, He F, Xu W, Yao K*. Hypoxia-induced deregulation of miR-126 and its regulative effect on VEGF and MMP-9 expression. Int J Med Sci. 2013 Dec 10;11(1):17-23.

Ye Panpan, Lin Kana, Li Zhaochun, Liu Jian, Yao Ke, Xu Wen*. Epigallocatechin gallate protects against apoptosis induced by high glucose in human lens epithelial cells. Mol Biol (Mosk). 2013;47(2):222-227.

Wang Qiwei, Yao Ke*, Xu Wen, Chen Peiqing, Shentu Xingchao, Xie Xin, Weng Yan, Zhang Li, Jin Chongfei, Wu Wei, Zhu Yanan, Yu Yinhui. Bromfenac sodium 0.1%, fluorometholone 0.1% and dexamethasone 0.1% for control of ocular inflammation and prevention of cystoid macular edema after phacoemulsification. Ophthalmologica. 2013;14.

Ye Panpan, Xu Wen*, Xu Hesheng, Li Zhaochun, Shi Junting, He Fengying, Yao Ke. Monogragh: Conductive keratoplasty: an approach for the correction of residual hypeopia in post-LASIK pseudophakia. Int J Ophthalmol. 2012;5(5):630-633.

Wang Qiwei, Xu Wen, Zhu Yanan, Li Jinyu, Zhang Li, Yao Ke*. Misdiagnosis induced intraocular lens dislocation in anterior megalophthalmos. Chin Med J (Engl). 2012;125(17):3180-3182.

Xu Wen, Ye Panpan*, Yao Ke, Li Zhaochun, He Fengying, Shi Junting, Liu Jun. Correction of extremehyperopia: Artisan iris-fixated intraocular lens implantation for pseudophakia after clear extraction. Int J Ophthalmol. 2011;4(4):454-457.

Ye Panpan, Xu Wen*, Tang Xiajing, Yao Ke, Li Zhaochun, Xu Hesheng, Shi Junting. Conductive keratoplasty for symptomatic presbyopia following monofocal intraocular lens implantation. Clin Exp Ophthalmol. 2011; 39:404-411.

Xu Wen*, Ye Panpan, Yao Ke, Ma Jin, Xu Hesheng. Conductive keratoplasty for the treatment of astigmatism induced by corneal trauma or incision. J Refract Surg. 2010;26(1):33-42.

Xu Wen*, Yao Ke, Wu Wei, Li Zhaochun, Ye Panpan. Change in outflow pathway of porcine eyes in vitro by nonpenetrating filtering surgery. Can J Ophthalmol. 2010;45(6):632-636.

Xu Wen*, Ye Panpan, Li Zhaochun, Shi Junting, Wang Wei, Yao Ke. Endostar, a recently introduced recombinant human endostatin, inhibits proliferation and migration through regulating growth factors, adhesion factors and inflammatory mediators in choroid-retinal endothelial cells. Mol Biol (Mosk). 2010;44(4):664-670.

Chen Zhiqing, Yao Ke*, Xu Wen, Wu Renyi. Inhibition of calpain expression by E- 64d in the rat retina subjected to ischemia/reperfusion injury. Mol Biol (Mosk). 2008;42(2): 258-264.

Yao Ke*, Tan Jian, Ye Panpan, Wang Kaijun, Xu Wen, Shentu Xingchao, Tang Xiajing. Integrin beta1-mediated signaling is involved in transforming growth factor- beta2-promoted migration in human lens epithelial cells. Mol Vis. 2007;20(13): 1769- 1776.

Yao Ke*, Rao Huiying, Wu Renyi, Tang Xiajing, Xu Wen. Expression of Hsp70 and Hsp27 in lens epithelial cells in cotused eye of rat modulated by thermotolerance or quercetin. Mol Vis. 2006;9(12):445-450.

Ni Ying, Wu Renyi*, Xu Wen,et al. Effect of CAMP on porcine ciliary transepithelial short-circuit current, sodium transport, and chloride transport. Invest Ophthalmol Vis Sci. 2006;47(5):2065-2074.

Yao Ke*, Wang Kaijun, Sun Zhaohui, Tan Jian, Xu Wen, Zhu Lijun, Lu Deqiang. Low power microwave radiation inhibits the proliferation of rabbit lens epithelial cells by upregulating P27Kip1 expression. Mol Vis. 2004;25(10):138-143.

Xu Wen, et al. Under a sealed slceral flap, effect of trabeculectomy and/or sclerectomy on outflow facility in perfused pig eyes. Ophthalmic Res. 2004;36(Suppl): 81.

Xu Wen, et al. Expression and proteolytic activity of calpain in lens epithelial cells of oxidative cataract. J Zhejiang Univ Sci. 2004;5(6):743-748.

Shentu Xingchao, Yao Ke*, Xu Wen, Zheng Shu, Hu Songnian, Gong Xiaohua. Special fasciculiform cataract caused by a mutation in the γD-crystallin gene. Mol Vis. 2004; 10:233-239.

Yao Ke*, Wang Kaijun, Xu Wen, et al. Caspase-3 and its inhibitor Ac-DEVD-CHO in rat lens epithelial cell apoptosis induced by hydrogen in vitro. Chin Med J. 2003;116(7):1034-1038.

Shentu Xingchao, Yao Ke*, Sun Chaohui, Xu Wen, Wu Renyi. Expression and effect of basic fibroblast growth factor on human cataract lens epithelial cells. Chin Med J (Engl). 2002;115(2):268-271.

Current Program

Research on new technologies for the prevention, diagnosis and treatment of important ocular surface diseases - personalized diagnosis and treatment of dry eyes and comprehensive prevention and treatment strategies. Funding Source: Major Science and Technology Projects of Zhejiang Province.

Corneal microstructure analysis based on angular resolution light scattering spectroscopy. Funding Source: Youth Science Foundation Project of National Natural Science Foundation of China.

Molecular pathology of new vascular glaucoma induced by argon laser and mechanism of inhibition of new blood vessels by recombinant endothelial cell suppressor. Funding Source: Natural Science Foundation of Zhejiang.

The pathogenesis and drug therapy of neovascular glaucoma. Funding Source: Public Welfare Technology Application Research Program of Zhejiang Provincial Department of Science and Technology.

Effect evaluation and mechanism of a new anti-glaucoma surgery for open Angle glaucoma. Funding Source: Health Commission of Zhejiang Co-construction Project.

Study on key techniques and quality control of primary cataract surgery. Funding Source: National Science and Technology Support Program of the Eleventh Five-year plan

Research on hematopoietic stem cell transplantation for experimental retinal necrosis. Funding Source: Natural Science Foundation of Zhejiang.

Study on the relationship between α-crystal protein and low intensity microwave irradiation induced lens injury. Funding Source: Natural Science Foundation of Zhejiang.

Molecular biology of lens injury caused by low intensity microwave radiation. Funding Source: Major Project Fund of Health Commission of Zhejiang Province.

Cell signal transduction pathway mediated by protein kinase C and the occurrence and prevention of PCO. Funding Source: Special Research Fund for Doctoral Programs in Institutions of Higher Learning.

Study on the effect of Calpain II and its inhibitors on cataract. Funding Source: Education Department of Zhejiang Province.

Experiment and clinical study on small incision cataract combined with glaucoma. Funding Source: Health Commission of Zhejiang Province.

Study on bacterial adhesion and growth inhibition of crystal epithelial cells on the surface of artificial crystal with different materials. Funding Source: Health Commission of Zhejiang Province.

A comparative study on the adhesion of bacteria and epithelial cells on different artificial crystal surfaces. Funding Source: Health Commission of Zhejiang Province.

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