Position：Vice Chair of Hematology
Department：Hematology
Medical School：Zhejiang University School of Medicine, China
Academic Rank：Professor
Hematological tumors including leukemia, lymphoma and multiple myeloma.
National Sci-Tech Advance Award, Second Prize
Young Investigator Scholar Award (AACR), Second Prize
151 Talent of Zhejiang Province
High-level Innovative Health Talents of Zhejiang Province.
Council Member, the 1st Board of Specialty Committee, Hematology of World Federation of Chinese Medicine Societies, 2016- present
Member, Society of Experimental Hematology, Chinese Association of Pathophysiology, 2019-present
Prof. Xu's research work mainly focuses on molecular etiology and mechanism of hematological malignancies, especially leukemia, as well as R&D of novel molecular-targeted tumor drugs. He has published over 50 peer-reviewed papers in Cancer Cell, Blood, Leukemia, Hepatology, Journal of Hepatology, Oncogene, etc., and has over 10 PCT patents.
Yu Q, Xu Y, Zhuang H, Wu Z, Zhang L, Li J, Yang L, Wu B, Wang P, Zhang X, Gan X, Liang Y, Zheng S, Yu X, Gu Y, Xu R*. Aberrant activation of RPB1 is critical for cell overgrowth in acute myeloid leukemia. Exp Cell Res. 2019;384(2):111653.
Yu Q, Wang P, Yang L, Wu Z, Li S, Xu Y, Wu B, Ma A, Gan X, Xu R*. Novel synthetic tosyl chloride-berbamine regresses lethal MYC-positive leukemia by targeting CaMKIIγ/Myc axis. Biomed Pharmacother. 2019;117:109134.
Gu Y, Zhang J, Ma X, Kim BW, Wang H, Li J, Pan Y, Xu Y, Ding L, Yang L, Guo C, Wu X, Wu J, Wu K, Gan X, Li G, Li L, Forman SJ, Chan WC, Xu R*, Huang W*. Stabilization of the c-Myc Protein by CAMKIIγ Promotes T Cell Lymphoma. Cancer Cell. 2017;32:115-128.
Gu Y, Zheng W, Zhang J, Gan X, Ma X, Meng Z, Chen T, Lu X, Wu Z, Huang W*, Xu R*. Aberrant activation of CaMKIIγ accelerates chronic myeloid leukemia blast crisis. Leukemia. 2016;30:1282-9.
Chen T, Meng Z, Gan Y, Wang X, Gu Y, Xu X, Tang J, Zhou H, Zhang X, Gan X, Van Ness C, Xu F, Xu G, Huang L, Zhang X, Fang Y, Wu J, Zheng S, Jin J, Huang W*, Xu R*.The viral oncogene Np9 acts as a critical molecular switch for co-activating β-catenin, ERK, Akt and Notch1 and promoting the growth of human leukemia stem/progenitor cells. Leukemia. 2013,27(1):1469-78.
Gu Y, Chen T, Meng Z, Gan Y, Xu X, Lou G, Li H, Gan X, Zhou H, Tang J, Xu G, Huang L, Zhang X, Fang Y, Wang K, Zheng S, Huang W*, Xu R*. CaMKII γ, a critical regulator of CML stem/progenitor cells, is a target of the natural product berbamine. Blood. 2012,120(24):4829-39.
The role and mechanism(s) of the novel oncogenic UBA2-WTIP fusion gene in refractory/relapsed acute myeloid leukemia. Funding Source: National Natural Science Foundation of China.
The role and mechanism(s) of a novel candidate oncogene Np17 in acute myeloid leukemia. Funding Source: National Natural Science Foundation of China.
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