Position：Vice President of SAHZU, Chair of Lung Transplant
Medical School：Nanjing Medical University, China
Academic Rank：Professor, Chief Physician
Dr. Chen specializes in the diagnosis and treatment of lung diseases. He excels at lung transplantation, thoracoscopic surgery, radical resection of lung cancer, comprehensive treatment of lung cancer and application of ECMO.
Dr. Chen is a top expert of lung transplant in China. He has completed over 1200 lung transplant since his first operation in 2002. He has chaired lung transplant programs in multiple Chinese medical centers, which all have been conducting over 100 lung transplants each year. Thanks to Dr. Chen's great efforts, the fast track system of donor organ transportation in China was established.
In February 2020, Dr. Chen completed world's first double lung transplant on a Covid-19 patient. In April 2020, he was appointed as the director of the national lung transplant program for Covid-19 patients. In February 2021, Dr. Chen performed China's first double lung-liver transplant.
Dr. Chen has published 3 books and over 170 research articles, including 40 in SCI journals such as Cell.
Scientific and Technological Progress Award of Hubei Province, First Prize, 2021
Chinese Doctor Award, 2020
Huaxia Medical Technology Award, First Prize, 2020
Chinese Medical Technology Award, Third Prize, 2020
Golden Lancet, 2017
Compassionate Doctor of the Yangtze River Delta Region, 2017
Young and Middle-Aged Scholars with Outstanding Contributions, National Health Commission, 2017
The 12th Excellent Respiratory Doctor of China, 2017
Chinese Medical Technology Award, Second Prize, 2017
Chinese Medical Technology Award, Second Prize, 2011
National Advanced Worker, 2005
National May Day Labor Medal, 2004
Standing Committee Member, Organ Transplant Committee, Chinese Medical Doctor Association
Vice Chairman, Working Committee of Organ Procurement and Allocation, Chinese Hospital Association
Standing Committee Member, Director of Lung Transplant Division, Transplant Committee, Chinese Medical Association
Member, Chinese Human Organ Donation and Transplant Committee
Executive Chair, Chinese Lung Transplant Alliance
Director, Lung Transplant Data Administration, National Health Commission
Director, National Lung Transplant Quality Control Center
Visiting Professor of Lung Transplant, Duke University, 2010
Visiting Professor of Lung Transplant, Toronto University, 2004
Visiting Professor of Lung Transplant, Toronto University, 2000-2001
Advanced Training in Thoracic Surgery, Beijing University People's Hospital, 2000
Master Degree, Nanjing Medical University, 1997-1999
Bachelor Degree in Clinical Medicine, Suzhou University, 1980-1985
Wu H, Yu Y, Huang H, Hu Y, Fu S, Wang Z, Shi M, Zhao X, Yuan J, Li J, Yang X, Bin E, Wei D, Zhang H, Zhang J, Yang C, Cai T, Dai H, Chen J, Tang N. Progressive Pulmonary Fibrosis Is Caused by Elevated Mechanical Tension on Alveolar Stem Cells. Cell. 2020. 180(1): 107-121.e17.
Chen JY, Wu H, Tang N. Pulmonary alveolar regeneration in adult COVID-19 patients. 2020 Cell Research,
Qiao K, Liu F, Wu B, Xu X, Jiao GQ, Lu RG, Li HX, Zhao J, Huang J, Yang Y, Lu XJ, Li JS, Jiang SY, Wang DP, Hu CX, Wang GL, Huang DX, Jiao GH, Wei D, Ye SG, Huang JA, Zhou L, Zhang XQ, He JX. Lung transplantation as therapeutic option in acute respiratory distress syndrome for COVID-19-related pulmonary fibrosis. Chin Med J (Engl). 2020.
Wei D, Gao F, Yang Z, Wang W, Chen Y, Lu Y, Chen J. Ex vivo lung perfusion with perfusate purification for human donor lungs following prolonged cold storage. Ann Transl Med. 2020. 8(3): 38.
Zhang Z, Ding H, Liu F, Chen J. Successful bilateral lung transplantation and simultaneous Nuss technique correction of pectus excavatum post-allogeneic haematopoietic stem cell transplantation. Interact Cardiovasc Thorac Surg. 2019.
Wei D, Gao F, Wu B, Zhou M, Zhang J, Yang H, Liu D, Fan L, Chen J. Single versus bilateral lung transplantation for idiopathic pulmonary fibrosis. Clin Respir J. 2019. 13(6): 376-383.
Huang L, Chen W, Guo L, Zhao L, Cao B, Liu Y, Lu B, Li B, Chen J, Wang C. Scopulariopsis/Microascus isolation in lung transplant recipients: A report of three cases and a review of the literature. Mycoses. 2019. 62(10): 883-892.
Tian Y, Li H, Gao Y, Liu C, Qiu T, Wu H, Cao M, Zhang Y, Ding H, Chen J, Cai H. Quantitative proteomic characterization of lung tissue in idiopathic pulmonary fibrosis. Clin Proteomics. 2019. 16: 6.
Qiu T, Tian Y, Gao Y, Ma M, Li H, Liu X, Wu H, Zhang Y, Ding H, Cao M, Zhang J, Dai J, Chen J, Cai H. PTEN loss regulates alveolar epithelial cell senescence in pulmonary fibrosis depending on Akt activation. Aging (Albany NY). 2019. 11(18): 7492-7509.
Nie X, Chen Y, Tan J, Dai Y, Mao W, Qin G, Ye S, Sun J, Yang Z, Chen J. MicroRNA-221-3p promotes pulmonary artery smooth muscle cells proliferation by targeting AXIN2 during pulmonary arterial hypertension. Vascul Pharmacol. 2019. 116: 24-35.
Hu CX, Chen WH, He JX, Jiang GN, Li XS, Wei D, Wu B, Zhang J, Wang C, Chen JY. Lung transplantation in China between 2015 and 2018. Chin Med J (Engl). 2019. 132(23): 2783-2789.
Wang Q, Yu MF, Zhang WJ, Liu BB, Zhao QY, Luo X, Xu H, She YS, Zang DA, Qiu JY, Shen J, Peng YB, Zhao P, Xue L, Chen W, Ma LQ, Nie X, Shen C, Chen S, Chen S, Liu Q, Dai J, Qin G, Zheng YM, Wang YX, Zhu Ge R, Chen J, Liu QH. Azithromycin inhibits muscarinic 2 receptor-activated and voltage-activated Ca2+ permeant ion channels and Ca2+ sensitization, relaxing airway smooth muscle contraction. Clin Exp Pharmacol Physiol. 2019 .
Luo X, Xue L, Xu H, Zhao QY, Wang Q, She YS, Zang DA, Shen J, Peng YB, Zhao P, Yu MF, Chen W, Ma LQ, Chen S, Chen S, Fu X, Hu S, Nie X, Shen C, Zou C, Qin G, Dai J, Ji G, Su Y, Hu S, Chen J, Liu QH. Polygonum aviculare L. extract and quercetin attenuate contraction in airway smooth muscle. Sci Rep. 2018. 8(1): 3114.
Gao F, Chen J, Wei D, Wu B, Zhou M. Lung transplantation for bronchiolitis obliterans syndrome after allogenic hematopoietic stem cell transplantation. Front Med. 2018. 12(2): 224-228.
Tian Y, Li H, Qiu T, Dai J, Zhang Y, Chen J, Cai H. Loss of PTEN induces lung fibrosis via alveolar epithelial cell senescence depending on NF-κB activation. Aging Cell. 2018 : e12858.
Wang Q, Wang J, Wang J, Hong S, Han F, Chen J, Chen G. HMGB1 induces lung fibroblast to myofibroblast differentiation through NF?κB?mediated TGF?β1 release. Mol Med Rep. 2017. 15(5): 3062-3068.
Huang H, Feng R, Li S, Wu B, Xu K, Xu Z, Chen J. A CARE-compliant case report: Lung transplantation for a Chinese young man with idiopathic pleuroparenchymal fibroelastosis. Medicine (Baltimore). 2017. 96(19): e6900.
Nie X, Tan J, Dai Y, Mao W, Chen Y, Qin G, Li G, Shen C, Zhao J, Chen J. Nur77 downregulation triggers pulmonary artery smooth muscle cell proliferation and migration in mice with hypoxic pulmonary hypertension via the Axin2-β-catenin signaling pathway. Vascul Pharmacol. 2016. 87: 230-241.
Li JQ, Xu HY, Li MQ, Chen JY. Effect of setting high APRV guided by expiratory inflection point of pressure-volume curve on oxygen delivery in canine models of severe acute respiratory distress syndrome. Exp Ther Med. 2016. 12(3): 1445-1449.
Nie X, Qin G, Mao W, Wang W, Chang Y, Wei D, Zhou M, Wu B, Chen J. Axis inhibition protein 2 deficiency leads to hypoxic pulmonary hypertension through β-catenin signaling pathway. J Hypertens. 2016. 34(5): 877-892.
Mao W, Chen J, Zheng M, Wu B, Zhu Y. Initial experience of lung transplantation at a single center in China. Transplant Proc. 2013. 45(1): 349-355.