Publications

Qi Y, He J, Zhang Y, Ge Q, Wang Q, Chen L, Xu J, Wang L, Chen X, Jia D, Lin Y, Xu C, Zhang Y, Hou T, Si J, Chen S, Wang L. Heat-inactivated Bifidobacterium adolescentis ameliorates colon senescence through Paneth-like-cell-mediated stem cell activation. Nat Commun. 2023 Sep 30;14(1):6121.

Lin Y, Fan L, Qi Y, Xu C, Jia D, Jiang Y, Chen S, Wang L. Bifidobacterium adolescentis induces Decorin+ macrophages via TLR2 to suppress colorectal carcinogenesis. J Exp Clin Cancer Res. 2023 Jul 18;42(1):172. doi: 10.1186/s13046-023-02746-6.

Chen S, Fan L, Lin Y, Qi Y, Xu C, Ge Q, Zhang Y, Wang Q, Jia D, Wang L, Si J, Wang L. Bifidobacterium adolescentis orchestrates CD143+ cancer-associated fibroblasts to suppress colorectal tumorigenesis by Wnt signaling-regulated GAS1. Cancer Commun (Lond). 2023 Aug 2. doi: 10.1002/cac2.12469.

Wu L, Xue M, Lai S, Chen J, Lin Y, Ding N, Zhong J, Chen S, Wang L. Hypoxia derived exosomes promote the proliferation and metastasis of colorectal cancer through the regulation of HIF-1α/miR-4299/ZBTB4. Life Sci. 2023 Sep 15;329:121872. doi: 10.1016/j.lfs.2023.121872.

Zhang Z, Xue M, Chen J, Wang Z, Ju F, Ni J, Sun J, Wu H, Zheng H, Lou Z, Zhang Y, Yang X, Chen S, Xi Y, Wang L. METTL14 Regulates Intestine Cellular Senescence through m6A Modification of Lamin B Receptor. Oxid Med Cell Longev. 2022 Dec 19;2022:9096436. 

Jia DJ, Wang QW, Hu YY, He JM, Ge QW, Qi YD, Chen LY, Zhang Y, Fan LN, Lin YF, Sun Y, Jiang Y, Wang L, Fang YF, He HQ, Pi XE, Liu W, Chen SJ, Wang LJ. Lactobacillus johnsonii alleviates colitis by TLR1/2-STAT3 mediated CD206⁺ macrophages^IL-10 activation. Gut Microbes. 2022 Jan-Dec;14(1):2145843. doi: 10.1080/19490976.2022.2145843. 

Chen S, Zhang L, Li M, Zhang Y, Sun M, Wang L, Lin J, Cui Y, Chen Q, Jin C, Li X, Wang B, Chen H, Zhou T, Wang L, Hsu CH, Zhuo W. Fusobacterium nucleatum reduces METTL3-mediated m6A modification and contributes to colorectal cancer metastasis. Nat Commun. 2022 Mar 10;13(1):1248. 

Wang H, Gao Y, Vafaei S, Yu Q, Zhang J, Wang L. A chemoresistance lncRNA signature for recurrence risk stratification of colon cancer patients with chemotherapy. Mol Ther Nucleic Acids. 2021 Dec 11;27:427-438. 

Zheng S, Wang J, Ding N, Chen W, Chen H, Xue M, Chen F, Ni J, Wang Z, Lin Z, Jiang H, Liu X, Wang L. Prodrug polymeric micelles integrating cancer-associated fibroblasts deactivation and synergistic chemotherapy for gastric cancer. J Nanobiotechnology. 2021 Nov 21;19(1):381.

Chen SJ, Chen LY, Qi YD, Xu JL, Ge QW, Fan YD, Chen D, Zhang YW, Wang L, Hou TY, Yang XH, Xi YM, Si JM, Kang LJ, Wang LJ. Bifidobacterium adolescentis regulates catalase activity and host metabolism and improves healthspan and lifespan in multiple species. Nature Aging. 2021 Nov; 1(11): 991-1001

Fan L, Xu C, Ge Q, Lin Y, Wong CC, Qi Y, Ye B, Lian Q, Zhuo W, Si J, Chen S, Wang L.  A. Muciniphila Suppresses Colorectal Tumorigenesis by Inducing TLR2/NLRP3-Mediated M1-Like TAMs. Cancer Immunol Res. 2021 Oct;9(10):1111-1124.

Ge Q, Jia D, Cen D, Qi Y, Shi C, Li J, Sang L, Yang LJ, He J, Lin A, Chen S, Wang L. Micropeptide ASAP encoded by LINC00467 promotes colorectal cancer progression by directly modulating ATP synthase activity. J Clin Invest. 2021 Nov 15;131(22):e152911. 

Sun Q, Guo D, Li S, Xu Y, Jiang M, Li Y, Duan H, Zhuo W, Liu W, Zhu S, Wang L, Zhou T. Combining gene expression signature with clinical features for survival stratification of gastric cancer. Genomics. 2021 Jul;113(4):2683-2694. 

Gao Y, Wang H, Li H, Ye X, Xia Y, Yuan S, Lu J, Xie X, Wang L, Zhang J. Integrated analyses of m1A regulator-mediated modification patterns in tumor microenvironment-infiltrating immune cells in colon cancer. Oncoimmunology. 2021 Jun 23;10(1):1936758.

Wang J, Chen S, Naga YM, Liu J, Dai M, Yang S, Wang L, Ye B. Esophageal Variceal Ligation Monotherapy versus Combined Ligation and Sclerotherapy for the Treatment of Esophageal Varices. Can J Gastroenterol Hepatol. 2021 Mar 29;2021:8856048. 

Ding N, Xu S, Zheng S, Ye Q, Xu L, Ling S, Xie S, Chen W, Zhang Z, Xue M, Lin Z, Xu X, Wang L. "Sweet tooth"-oriented SN38 prodrug delivery nanoplatform for targeted gastric cancer therapy. J Mater Chem B. 2021 Mar 28;9(12):2816-2830.

Chen W, Wang W, Sun X, Xie S, Xu X, Liu M, Yang C, Li M, Zhang W, Liu W, Wang L, Zhou T, Yang Y. NudCL2 regulates cell migration by stabilizing both myosin-9 and LIS1 with Hsp90. Cell Death Dis . 2020 Jul 14;11(7):534. doi: 10.1038/s41419-020-02739-9.

Zheng S, Zhang Y, Chen S, Zhang Z, Chen F, Zhang Z, Hu Z, Tian J, Wang L. A preliminary study of dual-band confocal laser endomicroscopy combined with image mosaic in the diagnosis of liver cancer. Nanomedicine 2020 Jun 30;29:102250. doi: 10.1016/j.nano.2020.102250.

He J, Ge Q, Lin Z, Shen W, Lin R, Wu J, Wang B, Lu Y, Chen L, Liu X, Zheng W, Zhang Y, Wang L, Wang K, Wang L, Zhuo W, Chen S. MiR-129-5p induces cell cycle arrest through modulating HOXC10/Cyclin D1 to inhibit gastric cancer progression. FASEB J. 2020 Jun;34(6):8544-8557.

Ge QW, Hu YY, He JM, Chen F, Wu LP, Tu XT, Qi YD, Zhang ZZ, Xue M, Chen SJ, Zhong J, Wang LJ. Zic1 suppresses gastric cancer metastasis by regulating Wnt/β-catenin signaling and epithelial-mesenchymal transition. FASEB 2020 Feb;34(2):2161-2172. doi: 10.1096/fj.201901372RR.

Chen SJ, Su TT, Zhang Y, Lee A, He JM, Ge QW, Wang L, Si JM, Zhuo W, Wang LJ. Fusobacterium nucleatum promotes colorectal cancer metastasis by modulating KRT7-AS/KRT7. Gut Microbes. 2020 May 3;11(3):511-525.

Xue M, Weng WH, Wang LJ. An unusual cause of acute massive lower gastrointestinal bleeding. Gastroenterology 2020 May;158(6):1550-1551.

Liu Y, Ye S, Zhu Y, He X, Pan J, Chen S, Ye B, Wang L. Impact of tumour size on metastasis and survival in patients with pancreatic neuroendocrine tumours (PNETs): A population based study. J Cancer 2019; 10(25):6349-6357.

Fu J, Wu L, Ge C, Xu T, Li D, Fu W, Wang L, Du J. De-escalating chemotherapy for stage II colon cancer?. Therap Adv Gastroenterol. 2019 Aug 22;12:1756284819867553.

Liu Y, Pan J, Pan X, Wu L, Bian J, Lin Z, Xue M, Su T, Lai S, Chen F, Ge Q, Chen L, Ye S, Zhu Y, Chen S, Wang L. Klotho-mediated targeting of CCL2 suppresses the induction of colorectal cancer progression by stromal cell senescent microenvironments. Mol Oncol 2019; 13(11):2460-2475.

Yuan J, Ma M, Guo Y, He B, Cai Z, Ye B, Xu L, Liu J, Ding J, Zheng Z, Duan J, Wang L. Delayed endoscopic removal of sharp foreign body in the esophagus increased clinical complications: An experience from multiple centers in China. Medicine (Baltimore) 2019; 98(26):e16146.

Xue M, Chen LY, Wang WJ, Su TT, Shi LH, Wang L, Zhang W, Si JM, Wang L, Chen SJ. HOTAIR induces the ubiquitination of Runx3 by interacting with Mex3b and enhances the invasion of gastric cancer cells. Gastric Cancer. 2018 Sep;21(5):756-764.

Chen F, Jin X, Guo Y, Wang L. A rare cause of gastric "volvulus". Gastrointest Endosc 2018 Nov;88(5):878-880.

30. Wu L, Chen F, Chen S, Wang L. The Lymph node ratio optimizes staging in patients with small intestinal neuroendocrine tumors. Neuroendocrinology. 2018;107(3):209-217.

Xue M, Shi L, Wang W, Chen S, Wang L. An Overview of Molecular Profiles in Ulcerative Colitis-Related Cancer. Inflamm Bowel Dis. 2018;24(9):1883-94. 32. Liu Y, He X, Pan J, Chen S, Wang L.  Prognostic role of Glasgow prognostic score in patients with colorectal cancer: evidence from population studies. Sci Rep. 2017 Jul 21;7(1):6144.

Fu J, Wu L, Jiang M, Li D, Jiang T, Fu W, Wang L, Du J. Real-world impact of non-breast cancer-specific death on overall survival in resectable breast cancer. Cancer. 2017 Jul 1;123(13):2432-2443.

Wang L, Lin Z, Chen S, Li J, Chen C, Huang Z, Ye B, Ding J, Li W, Wu L, Jiang Y, Meng L, Du Q, Si J. Ten-day bismuth-containing quadruple therapy is effective as first-line therapy for Helicobacter pylori-related chronic gastritis: a prospective randomized study in China. Clin Microbiol Infect. 2017 Jun;23(6):391-395.

Zhao GF, Xue M, Hu YY, Chen SJ, Wang LJ*. How common the diagnosis of gastric low grade dysplasia will be upgraded by endoscopic resection: a meta-analysis.  Plos One  2015;10(7):e0132699.

Hu YY, Lian QW, Lin ZH, Zhong J,Xue M, Wang LJ*. Diagnostic performance of magnifying narrow-band imaging for early gastric cancer: A meta-analysis. World J Gastroenterol. 2015;21(25):7884-94. 

Xue M, Chen XQ, Shi LH, Si JM, Wang LJ*, Chen SJ. Small bowel capsule endoscopy in patients with unexplained chronic abdominal pain or diarrhea: a systemic review. Gastrointestinal Endoscopy 2015;81(1):186-93. 

Wang L, Gala M, Yamamoto M, Pino MS, Kikuchi H, Shue DS, Shirasawa S, Austin TR, Lynch MP, Rueda BR, Zukerberg LR, Chung DC. Adrenomedullin is a therapeutic target in colorectal cancer. Int J Cancer 2014; 134:2041-50.

Wang LJ, Chen SJ, Xue M, Zhong J, Wang X,  Gan LH, Lam EKY, Liu X, Zhang JB, Zhou TH, Yu J, Jin HC, Si JM. Homeobox D10 gene, a candidate tumor suppressor, is downregulated through promoter hypermethylation and associated with gastric carcinogenesis. Molecular Medicine 2012;18:389-400. 

Zhong J, Chen SJ, Xue M, Du Q, Cai JT, Jin HC, Si JM, Wang LJ*.  ZIC1 modulates cell-cycle distributions and cell migration though regulation of Sonic hedgehog, PI3K and MAPK signaling pathways in gastric cancer. BMC Cancer 2012, 12:290. 

Gan LH, Chen SJ, Zhong J, Wang X, Lam EKY, Liu X, Zhang JB, Zhou TH, Yu J, Si JM, Wang LJ*, Jin HC. ZIC1 is downregulated through promoter hypermethylation, and functions as a tumor suppressor gene in colorectal cancer. PLoS ONE 2011;6(2):e16916.

Pan J, Zhong J, Gan LH, Chen SJ, Jin HC, Wang X, Wang LJ*. Klotho, an anti-senescence related gene, is frequently inactivated through promoter hypermethylation in colorectal cancer. Tumor Biol 2011; 32: 729-735.

Wang LJ, Wang X, Wang XJ, Pan J, Liu HQ, Zhang SJ, Lin XY, Lam EKY, Cui Y, Yu J, Jin HC. Klotho is silenced through promoter hypermethylation in gastric cancer. Am J Cancer Res 2011;1(1):111-119.

Wang LJ, Gala  M , Yamamoto  M , Pino  MS , Shue  DS ,  Shirasawa S , Zukerberg LR , Chung DC. Adrenomedullin is a novel K-RAS target gene that regulates cellular invasion and angiogenesis in hypoxia. Gastroenterology  2011;140(5): S163. 

Chen SJ, Zhong J, Zhou QY, Lu XF, Wang LJ*. The Regenerating Ia gene is overexpressed in atrophic gastritis rats with hypergastrinemia. Gastroenterol Res Pract 2011;2011:403956. Epub 2011 Sep 22.

Zhong J, Chen Y, Wang LJ. Irreformable hyponatremia：a case report of pituitary dysfunction with liver cirrhosis. Chin Med J 2011; 124(14):2234-2236.

Zhou QY, Lu XF, Gan LH, Chen SJ, Zhou TH, Wang LJ*, Si JM. Role of REG Iα in gastric carcinogenesis: gastrin-associated proliferative and anti-apoptotic activities. Mol Med Rep 2010; 3: 999-1005. 

Wang LJ, Jin HC, Wang X, Lam EKY, Zhang JB, Liu X, Yu J, Chan FKL, Si JM, Sung JJY. ZIC1 is downregulated through promoter hypermethylation in gastric cancer. Biochem Biophys Res Commun 2009; 379(4):959-63. 

Wang LJ, Zhou QY, Chen Y, Chen SJ, Xu M, Zhu FS, Si JM. Muscovite reverses gastric gland atrophy and intestinal metaplasia by promoting cytoprotection and cell proliferation in rats with atrophic gastritis. Digestion 2009 ;79(2):79-91.

Sun LM, Si JM, Chen SJ, Liu WL, Zhao L, Wang LJ. The establishment and clinical appliance of technique of mucosa marking targeting biopsy. Hepatogastroenterology 2009; 56:59-62. 

Zhao Y, Wang LJ, Si JM. Hookworm infection causing chronic anemia identified during a procedure for acute gastrointestinal bleeding: a case report. Cases Journal 2009; 2:105.

Chen MY, Cai JT, Du Q, Wang LJ. Sarcoidosis of spleen presenting with solitary thrombopenia. Eur J Intern Med. 2009;20(1):e12.

Chen Y, Chen Y, Liu WL, Zhou TH, Cai JT, Du Q, Wang LJ, Wu JG, Si JM. Therapeutic effects of rectal administration of muscovite on experimental colitis in rats. J Gastroenterol Hepatol. 2009;24(5):912-919.

Zhao Y, Zhou T, Li A, Yao H, He F, Wang LJ, Si JM. A potential role of collagens expression in distinguishing between premalignant and malignant lesions in stomach. Anatomic Records. 2009;292(5):692-700.

Chen SJ, Wang LJ*, Zhu Q, Cai JT, Chen T, Si JM. Effect of H pylori infection and its eradication on hyperammo-nemia and hepatic encephalopathy in cirrhotic patients. World J Gastroenterol 2008;14(12):1914-8. 

Zhu FS, Si JM, Wang LJ, Wang DF, Chen P. Effect of mica monomer powder on chief and parietal cells as well as G and D cells in gastric mucosa of chronic atrophic gastritis in rats. Chin J Integr Med 2008 ;14(2):111-6

Wang LJ, Chen SJ, Chen Z, Cai JT, Si JM. Morphological and pathologic changes of experimental chronic atrophic gastritis (CAG) and the regulating mechanism of protein expression in rats. Journal of Zhejiang University SCIENCE 2006;7(8):634-640.

Si JM, Sun LM, Fan YJ, Wang LJ. Trial of a novel endoscopic tattooing biopsy forceps on animal model. World J Gastroenterol 2005;11(12):1859-1861.

Si JM, Wang LJ, Sun LM, Dai N. Irritable bowel syndrome consulters in Zhejiang province: the symptoms pattern, predominant bowel habit subgroups and quality of life. World J Gastroenterol 2004;10(7):1059-1064. 

Si JM, Wang LJ, Chen SJ, Zhao L, Dai N. Quality of life and cost-effectiveness of combined therapy for reflux esophagitis. Journal of Zhejiang University SCIENCE 2003;4(5):602-606.