Leadership

Xiang Meixiang, M.D., Ph.D.

Position:Vice President, Vice Chair of Heart Center

Department:Cardiology

Medical School:  Zhejiang University School of Medicine, China

Academic Rank:  Professor of Medicine, Chief Physician


Clinical / Research Interests

Coronary Heart Disease

Hypertension

Arrthymia

Percutaneous Coronary Intervention (PCI) 

Pacemaker Implantation


Professional Highlights

Medicine Health Science and Technology Award of Zhejiang Province, First Prize, 2013

Zhejiang Scientific and Technological Progress Award, First Prize, 2013

Zhejiang Scientific and Technological Progress Award, First Prize, 2008


Professional Appointments

Fellowship, American College of Cardiology (FACC)

Committee Member, Academic Group of Arrhythmia, Chinese Society of Cardiology

Committee Member, Academic Group of Pacing, Chinese Society of Pacing and Electrophysiology 

Committee Member, Chinese Heart Rhythm Society (CHRS), Chinese Biomedical Engineering Committee

Vice President, Zhejiang Society of  Pacing and Electrophysiology

Standing Committee Member, Zhejiang Society of Cardiology

Vice Chair, Zhejiang Arrhythmia Society, Zhejiang Biomedical Engineering Committee

Vice Chair, Cardiovascular Rehabilitation Society, Zhejiang Rehabilitation Medicine Association

Vice Director, Quality Control Center of Cardiovascular Interventional Therapy of Zhejiang Province


Education Experience

Research Summary

Publications

Jian Chen, Wudi Li, Meixiang Xiang*. Burden of valvular heart disease, 1990-2017: Results from the Global Burden of Disease Study 2017. Journal of Global Health. 2020;10(2):020404. (Corresponding author)

Jian Shen#, Yongli Ji#, Mingjun Xie#, Haiming Zhao, Wanling Xuan, Li Yin, Xiaohua Yu, Fangfang Xu, Shengan Su, Jing Nie, Yao Xie, Qing Gao, Hong Ma, Xueying Ke, Zhenyu Shi, Jianzhong Fu, Zhenjie Liu*, Yong He*, Meixiang Xiang*. Cell-modified Bioprinted Microspheres for Vascular Regeneration. Materials Science and Engineering: C. 2020, 112:110896. (Co-corresponding author)

Xiaogen Chen#, Chunna Jin#, Lan Xie, Meixiang Xiang*. LCZ696 and Preservation of Renal Function in Heart Failure: A Meta-Analysis of 6 Randomized Trials. Reviews in Cardiovascular Medicine. 2020, 21(1):113-118. (Corresponding author)

Xiaoping Lin#, Yuankun Ma#, Zhejun Cai, Qiyuan Wang, Lihua Wang, Zhaoxia Huo, Dan Hu, Jian’an Wang, Meixiang Xiang*. Next-generation Sequencing Identified Novel Desmoplakin Frame-Shift Variant in Patients With Arrhythmogenic Cardiomyopathy. BMC Cardiovascular Disorders. 2020, 20(1):74. (Corresponding author)

Hui Ni#, Yiming Zhao#, Yongli Ji, Jian Shen, Meixiang Xiang*, Yao Xie*. Adipose-derived stem cells contribute to cardiovascular remodeling. Aging(Albany NY). 2019, 11(23):11756-11769. (Co-corresponding author)

Yidong Wang, Liangliang Jia, Yao Xie, Zhejun Cai, Zhenjie Liu, Jian Shen, Yi Lu, Yaping Wang, Shengan Su, Yuankun Ma, Meixiang Xiang*. Involvement of macrophage-derived exosomes in abdominal aortic aneurysms development. Atherosclerosis. 2019, 289:64-72. 

Yi Lu#, Yidong Wang#, Ting Weng, Zexin Chen, Xiujuan Sun, Jia Wei, Zhejun Cai*, Meixiang Xiang*. Association between metformin use and coronary artery calcification in type2 diabetic patients. Journal of diabetes research. 2019, 2019:9484717. (Co-corresponding author)

Sheng-an Su#, Yao Xie, Yuhao Zhang, Yutao Xi*, Jie Cheng, Meixiang Xiang*. Essential roles of EphrinB2 in mammalian heart: from development to diseases. Cell communication and signaling. 2019, 17(1):29. (Co-corresponding author)

Xiaoya Wang#, Yi Lu, Yao Xie, Jian Shen, Meixiang Xiang*. Emerging roles of proteoglycans in cardiac remodeling. International Journal of Cardiology. 2019, 278:192-198. (Corresponding author)

Zurong Fu#, Fei Li#, Liangliang Jia, Shengan Su, Yaping Wang, Zhejun Cai*, Meixiang Xiang*. Histone deacetylase 6 reduction promotes aortic valve calcification via an endoplasmic reticulum stress-mediated osteogenic pathway. The Journal of Thoracic and Cardiovascular Surgery. 2019, 158(2):408-417. (Co-corresponding author)

Liangliang Jia#, Yaping Wang#, Yidong Wang, Yuankun Ma, Jian Shen, Zurong Fu, Yue Wu, Sheng’an Su, Yuhao Zhang, Zhejun Cai*, Jian’an Wang*, Meixiang Xiang*. Heme oxygenase-1 in macrophages drives septic cardiac dysfunction via suppressing lysosomal degradation of inducible nitric oxide synthase. Circulation  Research. 2018, 122:1532-1544. (Co-corresponding author)

Jian Shen#, Yao Xie#, Zhenjie Liu#, Shuning Zhang, Yaping Wang, Liangliang Jia, Yidong Wang, Zhejun Cai, Hong Ma*, Meixiang Xiang*.Increased myocardial stiffness activates cardiac microvascular endothelial cell via VEGF paracrine signaling in cardiac hypertrophy. Journal of Molecular and Cellular Cardiology. 2018, 122: 140-151. (Co-corresponding author)

Yaping Wang#, Liangliang Jia#, Jian Shen, Yidong Wang, Zurong Fu, Sheng-an Su, Zhejun Cai*, Jian-an Wang, Meixiang Xiang*. Cathepsin B aggravates coxsackievirus B3-induced myocarditis through activating the inflammasome and promoting pyroptosis. Plos Pathogens. 2018, 14(1):e1006872. (Co-corresponding author)

Yan Lin#, Han Chen#, Yidong Wang, Chunna Jin, Xiaoping Lin, Cuncun Wang, Yi Lu, Zexin Chen, Jian-an Wang, Meixiang Xiang*. Association of serum ADAMTs 7 level and genetic variant rs 1994016 with acute coronary syndrome in a chinese population: a case control study. Atherosclerosis 2018, 275:312-318. (Corresponding author)

Yi-dong Wang#, Zhen-jie Liu, Jun Ren, Mei-xiang Xiang*. Pharmacological Therapy of Abdominal Aortic Aneurysm: An Update. Current Vascular Pharmacology. 2018, 16(2):114-124. (Corresponding author)

Yue Wu#, Sheng-an Su, Yao Xie, Jian Shen, Wei Zhu*, Meixiang Xiang*. Murine models of vascular endothelial injury: techniques and pathophysiology. Thrombosis Research, 2018, 169: 64-72. (Co-corresponding author)

Sheng-an Su#, Du Yang#, Yue Wu, Yao Xie, Wei Zhu, Zhejun Cai, Jian Shen, Zurong Fu, Liangliang Jia, Yidong Wang, Yaping Wang, Jian-an Wang, Meixiang Xiang*. EphrinB2 regulates cardiac fibrosis through modulating the interaction of Stat3 and TGF-β/Smad3 signaling. Circulation Research. 2017, 121: 617-627. (Corresponding author)

Zhejun Cai# *, Baoqing Liu#, Jia Wei#, Zurong Fu, Yidong Wang, Yaping Wang, Jian Shen, Liangliang Jia, Shengan Su, Xiaoya Wang, Xiaoping Lin, Han Chen, Fei Li*, Jian'an Wang, Meixiang Xiang*. Deficiency of CCAAT/enhancer-binding protein homologous protein (CHOP) prevents diet-induced aortic valve calcification in vivo. Aging Cell. 2017, 16(6): 1334-1341. (Co-corresponding author)

Yong ZHENG#, Qiang GU#, Hong-wu CHEN, Huai-ming PENG, Dong-yu JIA, Yu ZHOU, Mei-xiang XIANG*. Efficacy of amiodarone and lidocaine for preventing ventricular fibrillation after aortic cross-clamp release in open heart surgery: a meta-analysis of randomized controlled trials. J Zhejiang Univ Sci B. 2017;18(12):1113-1122. (Corresponding author)

Sheng-an Su, Du Yang, Wei Zhu,Zhejun Cai, Na Zhang, Lina Zhao, Jian-an Wang, Meixiang Xiang*. Interleulin-17A mediates cardioyocyte apoptosis through Stat3-iNOS pathway. BBA-Molecular Cell Research. 2016, 11:2784-2794. (Corresponding author)

Yi Lu, Yi-dong Wang, Xiao-ya Wang, Han Chen, Zhe-jun Cai, Mei-xiang Xiang*. SIRT3 in cardiovascular diseases: Emerging roles and therapeutic implications. International Journal of Cardiology. 2016, 220:700-705. (Corresponding author)

Du Yang, Chunna Jin, Hong Ma, Mingyuan Huang, Guo-ping Shi, Jianan Wang, Meixiang Xiang*. EphrinB2/EphB4 pathway in postnatal angiogenesis: a potential therapeutic target for ischemic cardiovascular disease. Angiogenesis. 2016, 19(3): 297-309. (Corresponding author)

Ya-ping Wang , Yao Xie, Hong Ma, Sheng-an Su, Yi-dong Wang, Jian-an Wang, Mei-xiang Xiang*. Regulatory T lymphocytes in myocardial infarction: A promising new therapeutic target. International Journal of Cardiology. 2016, 203:923-928. (Corresponding author)

Zhejun Cai, Li Shen, Hong Ma, Jin Yang, Du Yang, Han Chen, Jia Wei, Qiulun Lu, Dao Wen Wang, Meixiang Xiang*, Jian'an Wang*. Involvement of Endoplasmic Reticulum Stress-Mediated C/EBP Homologous Protein Activation in Coxsackievirus B3-Induced Acute Viral Myocarditis. Circulation Heart failure. 2015, 8(4): 809-818. (Co-corresponding author)

Bu-yun Xu, Mei-xiang Xiang*, Jian-an Wang. Endothelail Progenitor Cell and In-Stent Restenosis. Current Stem Cell Research & Therapy. 2015, 10(4): 364-71. (Corresponding author)

Mingyuan Huang, Du Yang, Meixiang Xiang*, Jianan Wang . Role of interleukin-6 in regulation of immune responses to remodeling after myocardial infarction. Heart Failure Reviews. 2015, 20(1): 25-38. (Corresponding author)

Zhi-Yu Wang, Meng Chen, Ling-Ling Zhu, Lu-Shan Ya, Su Zeng, Mei-Xiang Xiang*, Quan Zhou*. Pharmacokinetic drug interactions with clopidogrel: updated review and risk management in combination therapy. Therapeutics and Clinical risk management. 2015.11: 449-467 (Co-corresponding author)

Jing Wang, Jes S Lindholt, Galina K Sukhova, Michael A Shi, Mingcan Xia, Han Chen, Meixiang Xiang, Aina He, Yi Wang, Na Xiong, Peter Libby, Jian-An Wang, Guo-Ping Shi. IgE actions on CD4+ T cells, mast cells, and macrophages participate in the pathogenesis of experimental abdominal aortic aneurysms. EMBO Molecular Medicine. 2014, 6(7): 952-69. 

Mingyuan Huang, Lihan Wang, Hong Ma, JiananWang, Meixiang Xiang*. Lack of an association between interleukin-6 -174G/C polymorphism and circulating interleukin-6 levels in normal population: a meta-analysis. DNA Cell Biology. 2013, 32(11): 654-64.  (Corresponding author)

Sheng-an Su, Hong Ma, Li Shen, Mei-xiang Xiang*, Jian-an Wang. Interleukin-17 and acute coronary syndrome. Journal of Zhejiang University-Science B. 2013, 14(8): 664-669.(Corresponding author)

Li Shen, Hong Ma, Mei-Xiang Xiang*, Jian-An Wang*. Meta-analysis of cohort studies of baseline prehypertension and risk of coronary heart disease. American Journal of Cardiology. 2013, 15: 112(2): 266-271. (Co-corresponding author)

Han Chen, Jing Wang, Mei-Xiang Xiang, Yan Lin, Aina He, Chun-Na Jin, Jian Guan, Galina K. Sukhova, Peter Libby, Jian-An Wang, Guo-Ping Shi. Cathepsin S-mediated fibroblast trans-differentiation contributes to left ventricular remodelling after myocardial infarction. Cardiovascular Research. 2013, 100(1): 84-94. 

Li SHEN, Liu-guang Song, Hong MA, Chun-na JIN, Jian-an WANG, Mei-xiang XIANG*. Tea consumption and risk of stroke: a dose-response meta-analysis of prospective studies. Journal of Zhejiang University-Science B. 2012, 13(8): 652-62. (Corresponding author)

Chun-na JIN, Hong MA, Ya LIN, Jian-an WANG, Mei-xiang XIANG*. Association between SNP rs1800875, serum chymase and immunoglobulin E levels in patients with coronary heart disease. Journal of Zhejiang University-Science B. 2011, 12(8): 660-667. (Corresponding author)

Jing Wang#, Xiang Cheng#, Mei-xiang Xiang #, Mervi Alanne-Kinnunen, Jian-an Wang, Han Chen, Aina He, Xinghui Sun, Yan Lin, Ting-Ting Tang, Xin Tu,  Sara Sjoeberg, Galina K. Sukhova, Yu-Hua Liao, Daniel H.Conrad, Lunyin Yu, Toshiaki Kawakami, Petri T. Kovanen, Peter Libby, Guo-Ping Shi. IgE stimulates human and mouse arterial cell apoptosis and cytokine expression and promotes atherogenesis in Apoe(-/-) mice. Journal of Clinical Investigation. 2011, 121(9):3564-3577. (Co-first author)

Meixiang Xiang#, Jiusong Sun, Yan Lin, Jie Zhang, Han Chen, Dan Yang , Jian-an Wang, Guo-ping Shi. Usefulness of serum tryptase level as an independent biomarker for coronary plaque instability in a Chinese population. Atherosclerosis. 2011, 215(2): 494-499. 

Jiusong Sun, Galina K. Sukhova, Jie Zhang, Han Chen, Sara Sjöberg, Peter Libby, Meixiang Xiang, Jianan Wang, Christoph Peters, Thomas Reinheckel, Guo-Ping Shi. Cathepsin L activity is essential to elastase perfusion-induced abdominal aortic aneurysms in mice. Arteriosclerosis Thrombsis and Vascular Biology. 2011, 31(11): 2500-8. 

Xiao-Hong Pan, Song-Zhao Zhang, Hui-Qiang Chen, Mei-Xiang Xiang, Jian-An Wang. Spuriously High B-Type Natriuretic Peptide Level Caused by Human Antimouse Antibodies. Annals of Internal Medicine. 2011, 155(6): 407-8.

Shu-qin YING, Mei-xiang XIANG*, Lu FANG , Jian-an WANG. Temporal changes in circulating P-select, plasminogen activator inhibitor, magnesium, and creatine kinase after percutaneous coronary intervention. Journal of Zhejiang University-Science B. 2010, 11(8): 575-82. (Corrsponding author)

PAN Xiao-hong, ZHONG Wen-zhao, XIANG Mei-xiang*, XU Geng, SHAN Jiang, WANG Jian-an. Clinical outcomes of serolimus-eluting stents versus bare metal stents in ST-segment elevation myocardial infarction patients: a meta-analysis. Chinese Medical Journal. 2009, 122(1): 88-92. (Corresponding author)

Mei-xiang XIANG#, Ai-na HE, Jian-an WANG, Chun GUI. Protective paracrine effect of mesenchymal stem cells on cardiomyocytes. Journal of Zhejiang University-Science B (Biomedicine & Biotechnology). 2009, 10(8): 619-624. 

Meixiang Xiang#, Jianan Wang, Emel Kaplan, Peter Oettgen, Lewis Lipsitz , James P. Morgan, Jiang-yong Min. Antiapoptotic effect of implanted embryonic stem cell-derived early-differentiated cells in aging rats after myocardial infarction. Journals of Gerontology Series A-Biological Sciences and Medical Sciences. 2006, 61(12): 1219-1227.


Current Program

The role and mechanism of Piezo 1 in mechanical stress-induced cardiac hypertrophy and remodeling. Funding Source: Natural Science Foundation of China.

The study of effect and mechanism of interleukin-17 and its receptors mediated myocardial ischemia reperfusion injury in mice. Funding Source: National Natural Science Foundation of China.

Effect and Mechanism of EphrinB2/EphB4 signaling in mast cell mediated cardiac ischemia reperfusion injury. Funding Source: National Natural Science Foundation of China.

Clinical classification and treatment strategy of ischemic heart failure. Funding Source: National Science & Technology Pillar Program.

The vessel function monitoring and early intervention in the population with abnormal metabolism. Funding Source: Key Program of Science and Technology of Zhejiang.

The role and mechanism of Cathepsin S in the ventricular remodeling after myocardial infarction in mice. Funding Source: National Natural Science Foundation of China.


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