Leadership

Wang Jian'an, M.D., Ph.D., F.A.C.C.

Position:Head of SAHZU, Chair of Heart Center

Department:Cardiology

Medical School:Zhejiang University School of Medicine, China

Academic Rank:Professor of Medicine, Chief Physician

Clinical / Research Interests

Atherosclerosis

Coronary Heart Disease

Myocardial Infarction

Heart Failure

Valve Disease Interventional herapy

Professional Highlights

Ho Leung Ho Lee Foundation Award, 2018

Zhejiang Science and Technology Significant Contribution Award, 2016

Zhejiang Scientific and Technological Progress Award, First Place, 2013

The National Bethune Medal, 2012

State Scientific and Technological Progress Award, Second Place, 2012

Zhejiang Scientific and Technological Progress Award , First Place, 2008

Zhejiang Scientific and Technological Progress Award , Second Place, 2005

Scientific and Technological Progress Award, Education of Zhejiang Province, Second Place, 2005

Chinese Medical Science and Technology Award, Third Place, 2004

Zhejiang Scientific and Technological Progress Award, Third Place, 2002

Zhejiang Scientific and Technological Progress Award, Second Place, 2001 

Professional Appointments

Editor-in-Chief, JACC: Asia

Co-director, European CSI

Vice Chairman, Asian Society of Cardiology

Fellow of American College of Cardiology

Vice President, Chinese Society of Cardiology

Chairman, Zhejiang Provincial Cardiology Association

Director, Zhejiang Provincial Key Laboratory of Cardiology

Director, Zhejiang University Cardiovascular Institute


Education Experience

Advanced Training in Interventional Cardiology, Loma Linda Medical Center, USA

Advanced Training in Cardiology, Queen Mary Hospital, Hongkong

Research Summary

Development of transcatheter aortic valve interventional devices and valve repair devices with independent intellectual property rights.

Innovation on theory and technique of transcatheter aortic valve replacement (TAVR), especially supra-annular structure based sizing strategy (Hangzhou Solution), has significantly lowerd TAVR mortality and complication rates. This strategy now is widely accepted worldwide among cardiologists.

Proposition of important theories of cardiac function reconstruction after myocardial infarction, including the theory and scheme of hypoxic preconditioning of mesenchymal stem cells to improve cardiac function, and the discovery of important paracrine substances and molecular mechanisms.

Carrying out ongest cycle of non-human primate research in the field of cardiac function reconstruction. 

Publications

Ren K, Pu C, Yu L, Gao F, Wang L, Pan L, Jiang J, Li H, Xu Y, He W, Yan M, Liu X, Wang J. The first two cases of transcatheter mitral valve repair with ARTO system in Asia. World J Emerg Med. 2020;11(1):33-36. (Corresponding Author)

Wang L, Pu C, Kong M, Jiang J, Ren K, Gao F, Lin X, Yu L, He W, Yan M, Liu X, Wang J. The first four cases of successful NeoChord procedure in mainland China. World J Emerg Med. 2019;10(3):133-137. (Corresponding Author)

Ye F, Wang Y, Wu C, Howatt DA, Wu CH, Balakrishnan A, Mullick AE, Graham MJ, Danser AHJ, Wang J, Daugherty A, Lu HS. Angiotensinogen and Megalin Interactions Contribute to Atherosclerosis. Arterioscler Thromb Vasc Biol. 2019;39(2):150-155. (Corresponding Author)

Fan J, Liu X, Yu L, Sun Y, Jaiswal S, Zhu Q, Chen H, He Y, Wang L, Ren K, Wang J. Impact of tricuspid regurgitation and right ventricular dysfunction on outcomes after transcatheter aortic valve replacement: A systematic review and meta-analysis.Clin Cardiol. 2019;42(1):206-212. (Corresponding Author)

Yang F, Wu R, Jiang Z, Chen J, Nan J, Su S, Zhang N, Wang C, Zhao J, Ni C, Wang Y, Hu W, Zeng Z, Zhu K, Liu X, Hu X, Zhu W, Yu H, Huang J, Wang J. Leptin increases mitochondrial OPA1 via GSK3-mediated OMA1 ubiquitination to enhance therapeutic effects of mesenchymal stem cell transplantation. Cell Death Dis. 2018;9(5):556. (Corresponding Author)

Xiao C, Wang K, Xu Y, Hu H, Zhang N, Wang Y, Zhong Z, Zhao J, Li Q, Zhu D, Ke C, Zhong S, Wu X, Yu H, Zhu W, Chen J, Zhang J, Wang J, Hu X. Transplanted Mesenchymal Stem Cells Reduce Autophagic Flux in Infarcted Hearts via the Exosomal Transfer of mir-125b. Circ Res. 2018;123(5):564-578. (Co-Corresponding Author)

Jia L, Wang Y, Wang Y, Ma Y, Shen J, Fu Z, Wu Y, Su S, Zhang Y, Cai Z, Wang J, Xiang M. Heme Oxygenase-1 in Macrophages Drives Septic Cardiac Dysfunction via Suppressing Lysosomal Degradation of Inducible Nitric Oxide Synthase. Circ Res. 2018;122(11):1532-1544. (Co-Corresponding Author)

Shen J, Zhang N, Lin YN, Xiang P, Liu XB, Shan PF, Hu XY, Zhu W, Tang YL, Webster KA, Cai RZ, Schally A, Wang J, Yu H. Regulation of Vascular Calcification by Growth Hormone-Releasing Hormone and its Agonists. Circ Res. 2018;122(10):1395-1408. (Co-Corresponding Author)

Liu X, He Y, Zhu Q, Gao F, He W, Yu L, Zhou Q, Kong M, Wang J. Supra-annular structure assessment for self-expanding transcatheter heart valve size selection in patients with bicuspid aortic valve. Catheter Cardiovasc Interv. 2018;91(5):986-994. (Corresponding Author)

Zhu K, Wu Q, Ni C, Zhang P, Zhong Z, Wu Y, Wang Y, Xu Y, Kong M, Cheng H, Tao Z, Yang Q, Liang H, Jiang Y, Li Q, Zhao J, Huang J, Zhang F, Chen Q, Li Y, Chen J, Zhu W, Yu H, Zhang J, Yang HT, Hu X, Wang J. Lack of Remuscularization Following Transplantation of Human Embryonic Stem Cell-Derived Cardiovascular Progenitor Cells in Infarcted Nonhuman Primates.Circ Res. 2018;122(7):958-969. (Corresponding Author)

Lin X, Liu X, Wang L, Jiang J, Sun Y, Zhu Q, Chen Z, He Y, Hu P, Xu Q, Gao F, Lin Y, Jaiswal S, Xiang M, Wang J. Targeted next-generation sequencing identified ADAMTS5 as novel genetic substrate in patients with bicuspid aortic valve. Int J Cardiol. 2018;252:150-155. (Corresponding Author)

Zhu Q, Liu X, He W, He Y, Tang M, Sun Y, Xu X, Shi K, Kong H, Jiang J, Chen L, Chen J, Hu P, Xu Q, Wang J. Predictors of Thrombocytopenia after Self-Expandable Transcatheter Aortic Valve Replacement: A Single-Center Experience from China. Cardiology. 2018;139(3):151-158. (Corresponding Author)

Hu H, Nan J, Sun Y, Zhu D, Xiao C, Wang Y, Zhu L, Wu Y, Zhao J, Wu R, Chen J, Yu H, Hu X, Zhu W, Wang J. Electron leak from NDUFA13 within mitochondrial complex I attenuates ischemia-referfusion injury via dimerized STAT3. PNAS. 2017;114(45):11908-11913. (Corresponding Author)

Jiang J, Hu X, Xiang M, Wang J. Heart Center of SAHZU Transforming Into an Innovative Institute. Circ Res. 2017;121(8):917-919. (Corresponding Author)

Nan J, Hu H, Sun Y, Zhu L, Wang Y, Zhong Z, Zhao J, Zhang N, Wang Y, Wang Y, Ye J, Zhang L, Hu X, Zhu W, Wang J. TNFR2 Stimulation Promotes Mitochondrial Fusion via Stat3- and NF-kB-Dependent Activation of OPA1 Expression. Circ Res. 2017 ;121(4):392-410. (Corresponding Author)

Yu H, Lu K, Zhu J, Wang J. Stem cell therapy for ischemic heart diseases. Br Med Bull. 2017 , 6:1-20. (Corresponding Author)

Sun Y, Liu X, He Y, Tang M, Zhu Q, Xu X, Guo D, Shi K, Hu P, Wang L, Kong H, Jiang J, Lin X, Xu Q, Gao F, Wang J. Meta-Analysis of Impact of Diabetes Mellitus on Outcomes After Transcatheter Aortic Valve Implantation. Am J Cardiol. 2017; 119(4):623-9. (Corresponding Author)

Wang C, Chen H, Zhu W, Xu Y, Liu M, Zhu L, Yang F, Zhang L, Liu X, Zhong Z, Zhao J, Jiang J, Xiang M, Yu H, Hu X, Lu H, Wang J. Nicotine Accelerates Atherosclerosis in Apolipoprotein E-Deficient Mice by Activating α7 Nicotinic Acetylcholine Receptor on Mast Cells. Arterioscler Thromb Vasc Biol. 2017; 37(1):53-65. (Corresponding Author)

Tang M, Liu X, Lin C, He Y, Cai X, Xu Q, Hu P, Gao F, Jiang J, Lin X, Zhu Q, Wang L, Kong H, Yu Y, Wang J. Meta-Analysis of Outcomes and Evolution of Pulmonary Hypertension Before and After Transcatheter Aortic Valve Implantation. Am J Cardiol. 2017; 119(1):91-9. (Corresponding Author)

Zhang N, Ye F, Zhu W, Hu D, Xiao C, Nan J, Su S, Wang Y, Liu M, Gao K, Hu X, Chen J, Yu H, Xie X, Wang J. Cardiac ankyrin repeat protein attenuates cardiomyocyte apoptosis by upregulation of Bcl-2 expression. BBA-Mol Cel Res. 2016; 1863(12):3040-9. (Corresponding Author)

Liu M, Chen H, Jiang J, Zhang Z, Wang C, Zhang N, Dong L, Hu X, Zhu W, Yu H, Wang J. Stem cells and diabetic cardiomyopathy: from pathology to therapy. Heart Fail Rev. 2016; 21(6):723-36. (Corresponding Author)

Wang K, Jiang Z, Webster KA, Chen J, Hu H, Zhou Y, Zhao J, Wang L, Wang Y, Zhong Z, Ni C, Li QJ, Xiang C, Zhang L, Wu R, Zhu W, Yu H, Hu X, Wang J. Enhanced Cardioprotection by Human Endometrium Mesenchymal Stem Cells Driven by Exosomal MicroRNA-21. Stem Cells Transl Med. 2017;6(1):209-222. (Corresponding Author)

Hu X, Chen P, Wu Y, Wang K, Xu Y, Chen H, Zhang L, Wu R, Webster K, Yu H, Zhu W, Wang J. MiR-211/STAT5A Signaling Modulates Migration of Mesenchymal Stem Cells to Improve its Therapeutic Efficacy. Stem Cells. 2016; 34(7):1846-58. (Corresponding Author)

Liu M, Chen H, Jiang J, Zhang Z, Wang C, Zhang N, Dong L, Hu X, Zhu W, Yu H, Wang J. Stem cells and diabetic cardiomyopathy: from pathology to therapy. Heart Fail Rev. 2016; 21:723–36. (Corresponding Author)

Hu X, Yang H, Zhu Y, Wang J, Dong E. Chinese Basic Cardiovascular Research in Transition. Circ Res. 2016; 118(12):1876-9. (Corresponding Author)

Hu X, Xu Y, Zhong Z, WuY, Zhao J, Wang Y, Cheng H, Kong M, Zhang F, Chen Q, Sun J, Li Q, Jin J, Li Q, Chen L, Wang C, Zhan H, Fan Y, Yang Q, Yu L, Wu R, Liang J, Zhu J, Wang Y, Jin Y, Lin Y, Yan F, Jia L, Zhu W, Chen J, Yu H, Zhang J, Wang J. A Large-scale Investigation of Hypoxia-preconditioned Allogeneic Mesenchymal Stem Cells for Myocardial Repair in Non-human Primates: Paracrine Activity Without Remuscularization. Circ Res. 2016; 118(6):970-83. (Corresponding Author)

Cai Z, Shen L, Ma H, Yang J, Yang D, Chen H, Wei J, Lu Q, Wang D, Xiang M, Wang J. Involvement of Endoplasmic Reticulum Stress-Mediated C/EBP Homologous Protein Activation in Coxsackievirus B3-Induced Acute Viral Myocarditis. Circ Heart Fail. 2015; 8(4):809-18. (Corresponding Author)

Hu X, Zhang L, Jin J, Zhu W, Xu Y, Wu Y, Wang Y, Chen H, Webster KA, Chen H, Yu H, Wang J. Heparanase released from mesenchymal stem cells activates intergrin beta1/HIF-2alpha/Flk-1 signaling and promotes endothelial cell migration and angiogenesis. Stem Cells. 2015; 33(6):1850-62. (Corresponding Author)

Hu X, Huang X, Yang Q, Wang L, Sun J, Zhan H, Lin J, Pu Z, Jiang J, Sun Y, Xiang M, Liu X, Xie X, Yu X, Chen Z, Tse HF, Zhang J, Wang J. Safety and efficacy of intracoronary hypoxia-preconditioned bone marrow mononuclear cell administration for acute myocardial infarction patients: The CHINA-AMI randomized controlled trial. Int J Cardiol. 2015;184C:446-51. (Corresponding Author)

Liu X, Chen H, Zhu W, Chen H, Hu X, Jiang Z, Xu Y, Zhou Y, Wang K, Wang L, Chen P, Hu H, Wang C, Zhang N, Ma Q, Huang M, Hu D, Zhang L, Wu R, Wang Y, Xu Q, Yu H, Wang J. Transplantation of SIRT1 engineered aged MSCs improves cardiac function in a rat myocardial infarction model. J Heart Lung Transpl. 2014;33(10):1083-92. (Corresponding Author)

Hu X, Wu R, Jiang Z, Wang L, Chen P, Zhang L, Yang L, Wu Y, Chen H, Chen H, Xu Y, Zhou Y, Huang X, Webster KA, Yu H, Wang J. Leptin signaling is required for augmented therapeutic properties of mesenchymal stem cells conferred by hypoxia preconditioning. Stem Cells. 2014;32(10):2702-13. (Corresponding Author)

Hu X, Wu R, Shehadeh LA, Zhou Q, Jiang C, Huang X, Zhang L, Gao F, Liu X, Yu H, Webster KA, Wang J. Severe hypoxia exerts parallel and cell-specific regulation of gene expression and alternative splicing in human mesenchymal stem cells. BMC Genomics. 2014;15(1):303. (Corresponding Author)

Chen H, Liu X, Chen H, Cao J, Zhang L, Hu X, Wang J. Role of SIRT1 and AMPK in mesenchymal stem cells differentiation. Ageing Res Rev. 2014;13:55-64. (Corresponding Author)

Zhang Z, Wang J, Xu Y, Jiang Z, Wu R, Wang L, Chen P, Hu X, Yu H. Menstrual blood derived mesenchymal cells ameliorate cardiac fibrosis via inhibition of endothelial to mesenchymal transition in myocardial infarction. Int J Cardiol. 2013;168(2):1711-4. (Corresponding Author)

Chen H, Wang J, Xiang M, Lin Y, He A, Jin CN, Guan J, Sukhova GK, Libby P, Wang J, Shi GP. Cathepsin S-Mediated Fibroblast Trans-Differentiation Contributes to Left Ventricular Remodeling After Myocardial Infarction. Cardiovasc Res. 2013;100(1):84-94. (Co-Corresponding Author)

Jiang Z, Hu X, Yu H, Xu Y, Wang L, Chen H, Chen H, Wu R, Zhang Z, Xiang C, Webster KA, Wang J. Human endometrial stem cells confer enhanced myocardial salvage and regeneration by paracrine mechanisms. J Cel Mol Med. 2013;17(10):1247-60. (Corresponding Author)

Xie X, Wang Y, Zhang S, Zhang G, Xu Y, Bi H, Daugherty A, Wang J. Chinese red yeast rice attenuates the development of angiotensin II-induced abdominal aortic aneurysm and atherosclerosis. J Nutr Biochem. 2012;23(6):549-56. (Corresponding Author)

Hu X, Yu S, Fraser JL, Lu Z, Ogle ME, Wang J, Wei L. Transplantation of hypoxia-preconditioned mesenchymal stem cells improves infarcted heart function via enhanced survival of implanted cells and angiogenesis. J Thorac Cardiovasc Surg. 2008;135(4):799-808. (Co-Corresponding Author)

Zhang N, Li J, Luo R, Jiang J, Wang J. Bone marrow mesenchymal stem cells induce angiogenesis and attenuate the remodeling of diabetic cardiomyopathy. Exp Clin Endocrin Diabetes. 2008;116(2):104-11. (Corresponding Author)

Hu X, Wang J, Chen J, Luo R, He A, Xie X, Li J. Optimal temporal delivery of bone marrow mesenchymal stem cells in rats with myocardial infarction. Eur J Cardio-Thorac Surg. 2007;31(3):438-43. (Corresponding Author)

Wang J, Chung Ann Choo D, Zhang X, Yang Q, Xian T, Lu D, Jiang S. The effect of transient balloon occlusion of the mitral valve on left atrial appendage blood flow velocity and spontaneous echo contrast. Clin Cardiol. 2000;23(7):501-6. (First &Corresponding Author)


Current Program

Expansion of human pluripotent stem cell differentiation cardiac lineage and its efficacy and safety after transplantation. Funding Source: National Key Research and Development Program.

Study on the mechanism of GRIM19 moderately down-regulating stem cell survival through mitochondrial autophagy. Funding Source: National Natural Science Foundation of China.

Research on new techniques for the treatment of heart valve disease. Funding Source: Key Research and Development Project of Zhejiang Province.

The effect and mechanism of angiotensinogen on atherosclerosis. Funding Source:National Natural Science Foundation of China. 

Research on key issues of human embryonic stem cell-derived cells in the treatment of heart failure after myocardial infarction. Funding Source: National Program on Key Basic Research Project.

Construction of technology platform for clinical evaluation and research of new drugs for cardiovascular diseases. Funding Source: National Science and Technology Major Project.

Standardized treatment and key technologies for disasters and severe trauma. Funding Source: Ministry of Health of China.

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